Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways

Cancer vaccines targeting ‘self’ antigens that are expressed at consistently high levels by tumor cells are potentially useful in immunotherapy, but immunological tolerance may block their function. Here, we describe a novel, naked DNA vaccine encoding an alphavirus replicon (self-replicating mRNA)...

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Detalhes bibliográficos
Main Authors: Leitner, Wolfgang W., Hwang, Leroy N., Deveer, Michael J., Zhou, Aimin, Silverman, Robert H., Williams, Bryan R.G., Dubensky, Thomas W., Ying, Han, Restifo, Nicholas P.
Formato: Artigo
Idioma:English
Publicado em: 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484510/
https://ncbi.nlm.nih.gov/pubmed/12496961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmxx
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1484510/
https://ncbi.nlm.nih.gov/pubmed/12496961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmxx

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