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Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer

Most chemotherapeutic drugs kill cancer cells by indirectly activating checkpoint-mediated apoptosis after creating nonselective damage to DNA or microtubules, which accounts for their toxicity toward normal cells. We seek to target cancer cells by directly activating checkpoint regulators without c...

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Detalhes bibliográficos
Main Authors:	Li, Youzhi, Sun, Xiangao, LaMont, J. Thomas, Pardee, Arthur B., Li, Chiang J., Bora, Puran S., Hu, Zhiwei, Tezel, Tongalp H., Sohn, Jeong-Hyeon, Kang, Shin Goo, Cruz, Jose M. C., Bora, Nalini S., Garen, Alan, Kaplan, Henry J., LeCouter, Jennifer, Lin, Rui, Tejada, Max, Frantz, Gretchen, Peale, Franklin, Hillan, Kenneth J., Ferrara, Napoleone, Simões, Cristina, Jensen, Ole, Parkkonen, Lauri, Hari, Riitta, Pitari, G. M., Zingman, L. V., Hodgson, D. M., Alekseev, A. E., Kazerounian, S., Bienengraeber, M., Hajnóczky, G., Terzic, A., Waldman, S. A., Dewald, Oliver, Frangogiannis, Nikolaos G., Zoerlein, Martin, Duerr, Georg D., Klemm, Christina, Knuefermann, Pascal, Taffet, George, Michael, Lloyd H., Crapo, James D., Welz, Armin, Entman, Mark L., Kuznetsova, Anna V., Meller, Jaroslaw, Schnell, Phillip O., Nash, James A., Ignacak, Monika L., Sanchez, Yolanda, Conaway, Joan W., Conaway, Ronald C., Czyzyk-Krzeska, Maria F., Holbert, Sébastien, Dedeoglu, Alpaslan, Humbert, Sandrine, Saudou, Frédéric, Ferrante, Robert J., Néri, Christian, Ge, Qing, McManus, Michael T., Nguyen, Tam, Shen, Ching-Hung, Sharp, Phillip A., Eisen, Herman N., Chen, Jianzhu, Goldfine, Allison B., Bouche, Clara, Parker, Robert A., Kim, Caroline, Kerivan, Amy, Soeldner, J. Stuart, Martin, Blaise C., Warram, James H., Kahn, C. Ronald, Ziouzenkova, Ouliana, Perrey, Stephane, Asatryan, Liana, Hwang, Juliana, MacNaul, Karen L., Moller, David E., Rader, Daniel J., Sevanian, Alex, Zechner, Rudolf, Hoefler, Gerald, Plutzky, Jorge, Inaba, Takaaki, Sano, Hajime, Kawahito, Yutaka, Hla, Timothy, Akita, Kaoru, Toda, Munetoyo, Yamashina, Ikuo, Inoue, Mizue, Nakada, Hiroshi, Marijt, W. A. Erik, Heemskerk, Mirjam H. M., Kloosterboer, Freke M., Goulmy, Els, Kester, Michel G. D., van der Hoorn, Menno A. W. G., van Luxemburg-Heys, Simone A. P., Hoogeboom, Manja, Mutis, Tuna, Drijfhout, Jan Wouter, van Rood, Jon J., Willemze, Roel, Falkenburg, J. H. Frederik, Ma, Ke, Cilingiroglu, Mehmet, Otvos, James D., Ballantyne, Christie M., Marian, Ali J., Chan, Lawrence, Boheler, Kenneth R., Volkova, Maria, Morrell, Christopher, Garg, Rahul, Zhu, Yi, Margulies, Kenneth, Seymour, Anne-Marie, Lakatta, Edward G., Wei, Jun-Zhi, Hale, Kristina, Carta, Lynn, Platzer, Edward, Wong, Cynthie, Fang, Su-Chiung, Aroian, Raffi V., Wheeler, Robert T., Kupiec, Martin, Magnelli, Paula, Abeijon, Claudia, Fink, Gerald R., Guina, Tina, Purvine, Samuel O., Yi, Eugene C., Eng, Jimmy, Goodlett, David R., Aebersold, Ruedi, Miller, Samuel I., Miura, Yoshiharu, Misawa, Naoko, Kawano, Yuji, Okada, Hiroshi, Inagaki, Yoshio, Yamamoto, Naoki, Ito, Mamoru, Yagita, Hideo, Okumura, Ko, Mizusawa, Hidehiro, Koyanagi, Yoshio, Wilson, Joyce A., Jayasena, Sumedha, Khvorova, Anastasia, Sabatinos, Sarah, Rodrigue-Gervais, Ian Gaël, Arya, Sudha, Sarangi, Farida, Harris-Brandts, Marees, Beaulieu, Sylvie, Richardson, Christopher D., O'Rourke, Eyleen J., Chevalier, Catherine, Pinto, A. Viviana, Thiberge, Jean Michel, Ielpi, Luis, Labigne, Agnès, Radicella, J. Pablo, Kalkum, Markus, Lyon, Gholson J., Chait, Brian T., Bina, James, Zhu, Jun, Dziejman, Michelle, Faruque, Shah, Calderwood, Stephen, Mekalanos, John, Karniol, Baruch, Vierstra, Richard D., Mochida, Sumiko, Westenbroek, Ruth E., Yokoyama, Charles T., Itoh, Kanako, Catterall, William A., Zhong, Huijun, Myers, Scott J., Scheuer, Todd, Niquet, Jerome, Baldwin, Roger A., Allen, Suni G., Fujikawa, Denson G., Wasterlain, Claude G., Johnston, Jonathan D., Messager, Sophie, Ebling, Francis J. P., Williams, Lynda M., Barrett, Perry, Hazlerigg, David G., Gao, Wen-Jun, Goldman-Rakic, Patricia S., Nilsen, Jon, Brinton, Roberta Diaz, Kang, Kukjin, Shelley, Michael, Sompolinsky, Haim, Fagiolini, Michela, Katagiri, Hiroyuki, Miyamoto, Hiroyuki, Mori, Hisashi, Grant, Seth G. N., Mishina, Masayoshi, Hensch, Takao K., Temple, Elise, Deutsch, Gayle K., Poldrack, Russell A., Miller, Steven L., Tallal, Paula, Merzenich, Michael M., Gabrieli, John D. E., Paladini, Carlos A., Robinson, Siobhan, Morikawa, Hitoshi, Williams, John T., Palmiter, Richard D., Colgin, Laura Lee, Kubota, Don, Lynch, Gary, Weber, John T., De Zeeuw, Chris I., Linden, David J., Hansel, Christian, Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders, Haydar, Tarik F., Ang, Eugenius, Rakic, Pasko, Palma, Eleonora, Trettel, Flavia, Fucile, Sergio, Renzi, Massimiliano, Miledi, Ricardo, Eusebi, Fabrizio, Goodman, Ann B., Colbourne, Frederick, Grooms, Sonja Y., Zukin, R. Suzanne, Buchan, Alastair M., Bennett, Michael V. L., Duan, Wenzhen, Guo, Zhihong, Jiang, Haiyang, Ware, Melvin, Li, Xiao-Jiang, Mattson, Mark P., Rustay, Nathan R., Wahlsten, Douglas, Crabbe, John C., Parada, Carlos Amílcar, Vivancos, Gustavo Gameiro, Tambeli, Claudia Herrera, de Queiróz Cunha, Fernando, Ferreira, Sérgio Henrique, Erxleben, Christian, Gomez-Alegria, Claudio, Darden, Thomas, Mori, Yasuo, Birnbaumer, Lutz, Armstrong, David L., Silverman, William R., Roux, Benoît, Papazian, Diane M., Launikonis, Bradley S., Barnes, Melissa, Stephenson, D. George, Carbrey, Jennifer M., Gorelick-Feldman, Daniel A., Kozono, David, Praetorius, Jeppe, Nielsen, Søren, Agre, Peter, Schneider, Johanna S., Stone, Marielle K., Wynne-Edwards, Katherine E., Horton, Teresa H., Lydon, John, O'Malley, Bert, Levine, Jon E., Simeonidis, Simos, Castagliuolo, Ignazio, Pan, Amy, Liu, Jennifer, Wang, Chi-Chi, Mykoniatis, Andreas, Pasha, Asia, Valenick, Leyla, Sougioultzis, Stavros, Zhao, Dezheng, Pothoulakis, Charalabos
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	The National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC151399/ https://ncbi.nlm.nih.gov/pubmed/12598645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0538044100 https://ncbi.nlm.nih.gov/pmc/articles/PMC151400/ https://ncbi.nlm.nih.gov/pubmed/12589025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0438014100 https://ncbi.nlm.nih.gov/pmc/articles/PMC151401/ https://ncbi.nlm.nih.gov/pubmed/12604792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0337667100 https://ncbi.nlm.nih.gov/pmc/articles/PMC151402/ https://ncbi.nlm.nih.gov/pubmed/12598650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0437944100 https://ncbi.nlm.nih.gov/pmc/articles/PMC151403/ https://ncbi.nlm.nih.gov/pubmed/12594332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0434905100 https://ncbi.nlm.nih.gov/pmc/articles/PMC151404/ https://ncbi.nlm.nih.gov/pubmed/12586861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0438035100 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