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The In Vivo Susceptibility of Leishmania donovani to Sodium Stibogluconate Is Drug Specific and Can Be Reversed by Inhibiting Glutathione Biosynthesis

Resistance to pentavalent antimonial (Sb(v)) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (s...

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Detalhes bibliográficos
Main Authors:	Carter, K. C., Sundar, S., Spickett, C., Pereira, O. C., Mullen, A. B., Karlowsky, James A., Draghi, Deborah C., Jones, Mark E., Thornsberry, Clyde, Friedland, Ian R., Sahm, Daniel F., Riccio, Maria Letizia, Docquier, Jean-Denis, Dell'Amico, Emanuela, Luzzaro, Francesco, Amicosante, Gianfranco, Rossolini, Gian Maria, Yong, Dongeun, Shin, Jong Hee, Kim, Sinyoung, Lim, Youngsik, Yum, Jong Hwa, Lee, Kyungwon, Chong, Yunsop, Bauernfeind, Adolf, Magnet, Sophie, Smith, Terry-Ann, Zheng, Renjian, Nordmann, Patrice, Blanchard, John S., Matar, Madonna J., Ostrosky-Zeichner, Luis, Paetznick, Victor L., Rodriguez, Jose R., Chen, Enuo, Rex, John H., Sahly, Hany, Schubert, Sabine, Harder, Jürgen, Rautenberg, Peter, Ullmann, Uwe, Schröder, Jens, Podschun, Rainer, Kokai-Kun, John F., Walsh, Scott M., Chanturiya, Tanya, Mond, James J., Sabtcheva, Stefana, Galimand, Marc, Gerbaud, Guy, Courvalin, Patrice, Lambert, Thierry, Toro, Carlos, Rodés, Berta, Mendoza, Carmen de, Soriano, Vincent, Pfister, P., Risch, M., Brodersen, D. E., Böttger, E. C., Mammeri, Hedi, Poirel, Laurent, Mangeney, Nicole, Brown-Elliott, Barbara A., Crist, Christopher J., Mann, Linda B., Wilson, Rebecca W., Wallace, Jr., Richard J., Boyle-Vavra, Susan, Yin, Shaohui, Challapalli, Mamatha, Daum, Robert S., Tortoli, Enrico, Bartoloni, Alessandro, Erba, Maria Luigia, Levrè, Egle, Lombardi, Natalia, Mantella, Antonia, Mecocci, Lorenzo, Eing, Bodo Rolf, Lippelt, Lars, Lorentzen, Eva Ulla, Hafezi, Wali, Schlumberger, Wolfgang, Steinhagen, Katja, Kühn, Joachim Ewald, Boivin, Guy, Osterhaus, Albert D., Gaudreau, Annie, Jackson, Helen C., Groen, Jan, Ward, Penelope, Lam, Lee L., Pau, Chou-Pong, Dollard, Sheila C., Pellett, Philip E., Spira, Thomas J., Germer, Jeffrey J., Heimgartner, Paul J., Ilstrup, Duane M., Harmsen, W. Scott, Jenkins, Greg D., Patel, Robin, Darwin, Ling H., Cullen, Allison P., Arthur, Patrick M., Long, Carole D., Smith, Kim R., Girdner, Jennifer L., Hook III, Edward W., Quinn, Thomas C., Lorincz, Attila T., Heikkilä, Tero, Seppälä, Ilkka, Saxen, Harri, Panelius, Jaana, Yrjänäinen, Heta, Lahdenne, Pekka, Alcon, Sophie, Talarmin, Antoine, Debruyne, Monique, Falconar, Andrew, Deubel, Vincent, Flamand, Marie, Doherty, T. Mark, Demissie, Abebech, Olobo, Joseph, Wolday, Dawit, Britton, Sven, Eguale, Tewodros, Ravn, Pernille, Andersen, Peter, Maquelin, K., Choo-Smith, L.-P., Endtz, H. P., Bruining, H. A., Puppels, G. J., Lainson, F. A., Aitchison, K. D., Donachie, W., Thomson, J. R., Pussinen, P. J., Vilkuna-Rautiainen, T., Alfthan, G., Mattila, K., Asikainen, S., Zhao, Yuqi, Yu, Min, Miller, Johann W., Chen, Mingzhong, Bremer, Eric G., Kabat, William, Yogev, Ram, Lee, Ann S. G., Tang, Lynn L. H., Lim, Irene H. K., Bellamy, Richard, Wong, Sin-Yew, de Silva, G. D. I., Kantzanou, M., Justice, A., Massey, R. C., Wilkinson, A. R., Day, N. P. J., Peacock, S. J., Hamid, Mohamed E., Roth, Andreas, Landt, Olfert, Kroppenstedt, Reiner M., Goodfellow, Michael, Mauch, Harald, Kimura, Tatsuji, Rokuhara, Akinori, Sakamoto, Yoko, Yagi, Shintaro, Tanaka, Eiji, Kiyosawa, Kendo, Maki, Noboru, Larsen, Hans Henrik, Masur, Henry, Kovacs, Joseph A., Gill, Vee J., Silcott, Victoria A., Kogulan, Palaniandy, Maenza, Janine, Smith, Margo, Lucey, Daniel R., Fischer, Steven H., Morré, Servaas A., Munk, Christian, Persson, Kenneth, Krüger-Kjaer, Susanne, van Dijk, Rogier, Meijer, Chris J. L. M., van den Brule, Adriaan J. C., Weigle, Kristen A., Labrada, Luz Angela, Lozano, Caterin, Santrich, Cecilia, Barker, Douglas C., Wadowsky, Robert M., Castilla, Elias A., Laus, Stella, Kozy, Anita, Atchison, Robert W., Kingsley, Lawrence A., Ward, Joel I., Greenberg, David P., Mott, Jason, Muramatsu, Yasukazu, Seaton, Elizabeth, Martin, Carol, Reed, Stephen, Rikihisa, Yasuko, Atanassov, Christo, Pezennec, Leon, d'Alayer, Jacques, Grollier, Ghislaine, Picard, Bertrand, Fauchère, Jean-Louis, Saengjaruk, Patcharin, Chaicumpa, Wanpen, Watt, George, Bunyaraksyotin, Gaysorn, Wuthiekanun, Vanaporn, Tapchaisri, Pramuan, Sittinont, Chuanpit, Panaphut, Thanachai, Tomanakan, Kanchana, Sakolvaree, Yuwaporn, Chongsa-Nguan, Manas, Mahakunkijcharoen, Yuvadee, Kalambaheti, Thareerat, Naigowit, Pimjai, Wambangco, Michael Angelo L., Kurazono, Hisao, Hayashi, Hideo, Vargas, Kaaren G., Joly, Sophie, Vögtlin, A., Fraefel, C., Albini, S., Leutenegger, C. M., Schraner, E., Spiess, B., Lutz, H., Ackermann, M., Hirose, Kenji, Itoh, Ken-Ichiro, Nakajima, Hiroshi, Kurazono, Takayuki, Yamaguchi, Masanori, Moriya, Kazuo, Ezaki, Takayuki, Kawamura, Yoshiaki, Tamura, Kazumichi, Watanabe, Haruo, Yates, Malcolm D., Drobniewski, Francis A., Wilson, Stuart M., Suzuki, Yasuhiko, Suzuki, Aya, Tamaru, Aki, Katsukawa, Chihiro, Oda, Hajime, Vitali, Luca A., Zampaloni, Claudia, Prenna, Manuela, Ripa, Sandro, Díez, Soraya, Gómez, Beatriz L., Restrepo, Angela, Hay, Rod J., Hamilton, Andrew J., Dautle, Melanie P., Ulrich, Ricky L., Hughes, Thomas A., Matsuzaki, Y., Sugawara, K., Mizuta, K., Tsuchiya, E., Muraki, Y., Hongo, S., Suzuki, H., Nakamura, K., Haile, D. T., Hughes, J., Vetter, E., Kohner, P., Snyder, R., Patel, R., Cockerill III, F. R., Cloughley, R., Kelehan, J., Corbett-Feeney, G., Murray, M., Callaghan, J., Regan, P., Cormican, M., Cloud, J. L., Neal, H., Rosenberry, R., Turenne, C. Y., Jama, M., Hillyard, D. R., Carroll, K. C.
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	American Society for Microbiology 2003
Assuntos:	Mechanisms of Resistance Susceptibility Experimental Therapeutics Letter to the Editor Erratum Case Reports Virology Chlamydiology and Rickettsiology Bacteriology Mycobacteriology and Aerobic Actinomycetes Mycology Clinical Veterinary Microbiology Epidemiology
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https://ncbi.nlm.nih.gov/pubmed/11825975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.588-593.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153358/ https://ncbi.nlm.nih.gov/pubmed/11825965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.512-518.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153359/ https://ncbi.nlm.nih.gov/pubmed/11825994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.675-678.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153360/ https://ncbi.nlm.nih.gov/pubmed/11825989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.657-659.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153361/ https://ncbi.nlm.nih.gov/pubmed/11825946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.382-388.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153362/ https://ncbi.nlm.nih.gov/pubmed/11826003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.40.2.707-711.2002 https://ncbi.nlm.nih.gov/pmc/articles/PMC153363/ 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The In Vivo Susceptibility of Leishmania donovani to Sodium Stibogluconate Is Drug Specific and Can Be Reversed by Inhibiting Glutathione Biosynthesis

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