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Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst

Proposing that a blend of the chemical diversity of small synthetic molecules with the immunological characteristics of the antibody molecule will lead to therapeutic agents with superior properties, we here present a device that equips small synthetic molecules with both effector function and long...

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Detalhes bibliográficos
Main Authors:	Rader, Christoph, Sinha, Subhash C., Popkov, Mikhail, Lerner, Richard A., Barbas, Carlos F., Malins, Donald C., Johnson, Paul M., Barker, Edward A., Polissar, Nayak L., Wheeler, Thomas M., Anderson, Katie M., Smith, Robin A. J., Porteous, Carolyn M., Gane, Alison M., Murphy, Michael P., Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., Hubbell, J. A., Laffitte, Bryan A., Chao, Lily C., Li, Jing, Walczak, Robert, Hummasti, Sarah, Joseph, Sean B., Castrillo, Antonio, Wilpitz, Damien C., Mangelsdorf, David J., Collins, Jon L., Saez, Enrique, Tontonoz, Peter, Spiotto, Michael T., Reth, Michael A., Schreiber, Hans, Kondo, Seiji, Lu, Ying, Debbas, Michael, Lin, Athena W., Sarosi, Ildiko, Itie, Annick, Wakeham, Andrew, Tuan, JoAnn, Saris, Chris, Elliott, Gary, Ma, Weili, Benchimol, Samuel, Lowe, Scott W., Mak, Tak Wah, Thukral, Sushil K., Fratti, Rutilio A., Chua, Jennifer, Vergne, Isabelle, Deretic, Vojo, Li, Yinuo, Sun, Hong, Ma, Xiaoyuan, Lu, Ann, Lux, Renate, Zusman, David, Shi, Wenyuan, Mao, Hanbin, Cremer, Paul S., Manson, Michael D., Seshadri, Rekha, Paulsen, Ian T., Eisen, Jonathan A., Read, Timothy D., Nelson, Karen E., Nelson, William C., Ward, Naomi L., Tettelin, Hervé, Davidsen, Tanja M., Beanan, Maureen J., Deboy, Robert T., Daugherty, Sean C., Brinkac, Lauren M., Madupu, Ramana, Dodson, Robert J., Khouri, Hoda M., Lee, Kathy H., Carty, Heather A., Scanlan, David, Heinzen, Robert A., Thompson, Herbert A., Samuel, James E., Fraser, Claire M., Heidelberg, John F., Imamizu, Hiroshi, Kuroda, Tomoe, Miyauchi, Satoru, Yoshioka, Toshinori, Kawato, Mitsuo, Roelfsema, Pieter R., Khayat, Paul S., Spekreijse, Henk, Teismann, Peter, Tieu, Kim, Choi, Dong-Kug, Wu, Du-Chu, Naini, Ali, Hunot, Stéphane, Vila, Miquel, Jackson-Lewis, Vernice, Przedborski, Serge, Dong, Erbo, Caruncho, Hector, Liu, Wen Sheng, Smalheiser, Neil R., Grayson, Dennis R., Costa, Erminio, Guidotti, Alessandro, Dzitoyeva, Svetlana, Dimitrijevic, Nikola, Manev, Hari, Díaz, Elva, Yang, Yee Hwa, Ferreira, Todd, Loh, Kenneth C., Okazaki, Yasushi, Hayashizaki, Yoshihide, Tessier-Lavigne, Marc, Speed, Terence P., Ngai, John, Carr, Laurie, Iacoboni, Marco, Dubeau, Marie-Charlotte, Mazziotta, John C., Lenzi, Gian Luigi, Savić, Nataša, Lüthi, Andreas, Gähwiler, Beat H., McKinney, R. Anne, Zhong, Haining, Lai, Jun, Yau, King-Wai, Göpfert, M. C., Robert, D., Edelman, Gerald M., Kopin, Alan S., McBride, Edward W., Chen, Ci, Freidinger, Roger M., Chen, Duan, Zhao, Chun-Mei, Beinborn, Martin, Cirino, Giuseppe, Sorrentino, Raffaella, di Villa Bianca, Roberta d'Emmanuele, Popolo, Ada, Palmieri, Alessandro, Imbimbo, Ciro, Fusco, Ferdinando, Longo, Nicola, Tajana, Gianfranco, Ignarro, Louis J., Mirone, Vincenzo, Paolocci, Nazareno, Katori, Tatsuo, Champion, Hunter C., St. John, Marcus E., Miranda, Katrina M., Fukuto, Jon M., Wink, David A., Kass, David A., Mangoni, Matteo E., Couette, Brigitte, Bourinet, Emmanuel, Platzer, Josef, Reimer, Daniel, Striessnig, Jörg, Nargeot, Joël, Hosy, Eric, Vavasseur, Alain, Mouline, Karine, Dreyer, Ingo, Gaymard, Frédéric, Porée, Fabien, Boucherez, Jossia, Lebaudy, Anne, Bouchez, David, Véry, Anne-Aliénor, Simonneau, Thierry, Thibaud, Jean-Baptiste, Sentenac, Hervé, Hückelhoven, Ralph, Dechert, Cornelia, Kogel, Karl-Heinz, Wyrzykowska, Joanna, Fleming, Andrew, Čeponienė, R., Lepistö, T., Shestakova, A., Vanhala, R., Alku, P., Näätänen, R., Yaguchi, K., Jakubowski, Simon J., Krishnamoorthy, Vidhya, Christie, Peter J., Ramos, Juan-Luis, O'Toole, George A., Mikalsen, Bjørg, Boison, Gudrun, Skulberg, Olav M., Fastner, Jutta, Davies, William, Gabrielsen, Tove M., Rudi, Knut, Jakobsen, Kjetill S., Hove-Jensen, Bjarne, Rosenkrantz, Tina J., Haldimann, Andreas, Wanner, Barry L., Muse, Wilson B., Rosario, Christopher J., Bender, Robert A., Robertson, Gregory T., Ng, Wai-Leung, Gilmour, Raymond, Winkler, Malcolm E., Sampson, S. L., Warren, R. M., Richardson, M., Victor, T. C., Jordaan, A. M., van der Spuy, G. D., van Helden, P. D., Barnhart, Michelle M., Sauer, Frederic G., Pinkner, Jerome S., Hultgren, Scott J., Dobinsky, Sabine, Kiel, Kathrin, Rohde, Holger, Bartscht, Katrin, Knobloch, Johannes K.-M., Horstkotte, Matthias A., Mack, Dietrich, Reed, Jennifer L., Palsson, Bernhard Ø., Ibarra, J. Antonio, Villalba, Miryam I., Puente, José Luis, Ackerley, David F., Caradoc-Davies, Tom T., Lamont, Iain L., Fedhila, Sinda, Gohar, Michel, Slamti, Leyla, Nel, Patricia, Lereclus, Didier, Teyssier, Corinne, Marchandin, Hélène, Siméon De Buochberg, Michèle, Ramuz, Michel, Jumas-Bilak, Estelle, Shimoji, Yoshihiro, Ogawa, Yohsuke, Osaki, Makoto, Kabeya, Hidenori, Maruyama, Soichi, Mikami, Takeshi, Sekizaki, Tsutomu, Finelli, Antonio, Gallant, Claude V., Jarvi, Keith, Burrows, Lori L., Bae, Taeok, Schneewind, Olaf, Chakrabarty, A. M., Palacios, Sergio, Starai, Vincent J., Escalante-Semerena, Jorge C.
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	The National Academy of Sciences 2003
Assuntos:	Biological Sciences Microbial Cell Biology Guest Commentary Population Genetics and Evolution Physiology and Metabolism Gene Regulation Molecular Biology of Pathogens Minireview Enzymes and Proteins Genetics and Molecular Biology Microbial Communities and Interactions
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC154356/ https://ncbi.nlm.nih.gov/pubmed/12702756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931308100 https://ncbi.nlm.nih.gov/pmc/articles/PMC154357/ https://ncbi.nlm.nih.gov/pubmed/12702759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931396100 https://ncbi.nlm.nih.gov/pmc/articles/PMC154358/ https://ncbi.nlm.nih.gov/pubmed/12697897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0931245100 https://ncbi.nlm.nih.gov/pmc/articles/PMC154359/ https://ncbi.nlm.nih.gov/pubmed/12686696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0737381100 https://ncbi.nlm.nih.gov/pmc/articles/PMC154360/ https://ncbi.nlm.nih.gov/pubmed/12697904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0830671100 https://ncbi.nlm.nih.gov/pmc/articles/PMC154361/ https://ncbi.nlm.nih.gov/pubmed/12702750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0930140100 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https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2867-2878.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154387/ https://ncbi.nlm.nih.gov/pubmed/12700247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2690-2691.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154388/ https://ncbi.nlm.nih.gov/pubmed/12700246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2687-2689.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154389/ https://ncbi.nlm.nih.gov/pubmed/12700256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2774-2785.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154390/ https://ncbi.nlm.nih.gov/pubmed/12700258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2793-2801.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154391/ https://ncbi.nlm.nih.gov/pubmed/12700271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.9.2920-2926.2003 https://ncbi.nlm.nih.gov/pmc/articles/PMC154392/ https://ncbi.nlm.nih.gov/pubmed/12700276 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Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst

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