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The stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptors

1. The locomotor stimulatory effects induced by caffeine (1,3,7-trimethylxanthine) in rodents have been attributed to antagonism of adenosine A(1) and A(2A) receptors. Little is known about its locomotor depressant effects seen when acutely administered at high doses. The roles of adenosine A(1) and...

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Detalhes bibliográficos
Main Authors: Yacoubi, Malika El, Ledent, Catherine, Ménard, Jean-François, Parmentier, Marc, Costentin, Jean, Vaugeois, Jean-Marie
Formato: Artigo
Idioma:English
Publicado em: 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1571962/
https://ncbi.nlm.nih.gov/pubmed/10742303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703170
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