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Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4(+) T cells

Multiple myelomas produce tumor-specific antigen (TSA) in the form of idiotype (Id) on monoclonal Ig. CD4(+) T cells can recognize Id-peptide on MHC class II molecules and protect against challenges with MOPC315 cells, which are, as common for myelomas, class II-negative. The present study explains...

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Detalhes bibliográficos
Main Authors:	Dembic, Zlatko, Schenck, Karl, Bogen, Bjarne, Bynoe, Margaret S., Grimaldi, Christine M., Diamond, Betty, Migueles, Stephen A., Sabbaghian, M. Shirin, Shupert, W. Lesley, Bettinotti, Maria P., Marincola, Francesco M., Martino, Lisa, Hallahan, Clair W., Selig, Sara M., Schwartz, David, Sullivan, John, Connors, Mark, Gong, Jianlin, Avigan, David, Chen, Dongshu, Wu, Zekui, Koido, Shigeo, Kashiwaba, Masahiro, Kufe, Donald, Wang, Z.-G., Williams, L. J., Zhang, X.-F., Zatorski, A., Kudryashov, V., Ragupathi, G., Spassova, M., Bornmann, W., Slovin, S. F., Scher, H. I., Livingston, P. O., Lloyd, K. O., Danishefsky, S. J., Belz, Gabrielle T., Stevenson, Philip G., Castrucci, Maria R., Altman, John D., Doherty, Peter C., Kim, Sungjin, Iizuka, Koho, Aguila, Hector L., Weissman, Irving L., Yokoyama, Wayne M., Nisitani, Sazuku, Satterthwaite, Anne B., Akashi, Koichi, Witte, Owen N., Wahl, Matthew I., Levine, Matthew H., Haberman, Ann M., Sant'Angelo, Derek B., Hannum, Lynn G., Cancro, Michael P., Janeway, Charles A., Shlomchik, Mark J., Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Senn, Beatrice M., Ochsenbein, Adrian F., Hengartner, Hans, Zinkernagel, Rolf M., Hayashi, Katsuhiko, Nittono, Ryo, Okamoto, Noriaki, Tsuji, Sachiyo, Hara, Yasushi, Goitsuka, Ryo, Kitamura, Daisuke, Saccani, Alessandra, Saccani, Simona, Orlando, Simone, Sironi, Marina, Bernasconi, Sergio, Ghezzi, Pietro, Mantovani, Alberto, Sica, Antonio, Ntziachristos, Vasilis, Yodh, A. G., Schnall, Mitchell, Chance, Britton, Schaffner, Claudia, Idler, Irina, Stilgenbauer, Stephan, Döhner, Hartmut, Lichter, Peter, Harvell, Djuana M. E., Strecker, Tracy E., Tochacek, Martin, Xie, Benjamin, Pennington, Karen L., McComb, Rodney D., Roy, Shyamal K., Shull, James D., Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., Iyer, Meera, Namavari, Mohammad, Phelps, Michael E., Herschman, Harvey R., Sen, Malini, Lauterbach, Kevin, El-Gabalawy, Hani, Firestein, Gary S., Corr, Maripat, Carson, Dennis A., Caslini, Corrado, Shilatifard, Ali, Yang, Liping, Hess, Jay L., Ware, Jerry, Russell, Susan, Ruggeri, Zaverio M., Asif, Mohammad, Egan, John, Vasan, Sara, Jyothirmayi, Garikiparthy N., Masurekar, Malthi R., Lopez, Santos, Williams, Chandra, Torres, Ramon L., Wagle, Dilip, Ulrich, Peter, Cerami, Anthony, Brines, Michael, Regan, Timothy J., Megonigal, Maureen D., Cheung, Nai-Kong V., Rappaport, Eric F., Nowell, Peter C., Wilson, Robert B., Jones, Douglas H., Addya, Kathakali, Leonard, Debra G. B., Kushner, Brian H., Williams, Terence M., Lange, Beverly J., Felix, Carolyn A., Liu, Kan, Paterson, Andrew J., Chin, Edward, Kudlow, Jeffrey E., Weinberg, Joel M., Venkatachalam, Manjeri A., Roeser, Nancy F., Nissim, Itzhak, Tesauro, M., Thompson, W. C., Rogliani, P., Qi, L., Chaudhary, P. P., Moss, J., Poelzl, Gerhard, Kasai, Yasuyo, Mochizuki, Naoki, Shaul, Philip W., Brown, Myles, Mendelsohn, Michael E., Zilber, Marie-Thérèse, Gregory, Stéphane, Mallone, Roberto, Deaglio, Silvia, Malavasi, Fabio, Charron, Dominique, Gelin, Catherine, Dhabhar, Firdaus S., Satoskar, Abhay R., Bluethmann, Horst, David, John R., McEwen, Bruce S., Yuan, Quan, Zhao, Fangping, Chung, Siu-Wah, Fan, Peidong, Sultzer, Barnet M., Kan, Y. W., Wong, Peter M. C., Cue, David, Southern, Sarka O., Southern, Peter J., Prabhakar, Jadhar, Lorelli, William, Smallheer, Joanne M., Mousa, Shaker A., Cleary, P. Patrick, Jean, François, Thomas, Laurel, Molloy, Sean S., Liu, Gseping, Jarvis, Michael A., Nelson, Jay A., Thomas, Gary, Rouquier, Sylvie, Blancher, Antoine, Giorgi, Dominique, Hartmann, Andreas, Hunot, Stéphane, Michel, Patrick P., Muriel, Marie-Paule, Vyas, Sheela, Faucheux, Baptiste A., Mouatt-Prigent, Annick, Turmel, Hélène, Srinivasan, Anu, Ruberg, Merle, Evan, Gerard I., Agid, Yves, Hirsch, Etienne C., McNay, Ewan C., Fries, Thomas M., Gold, Paul E., Wong, Philip C., Waggoner, Darrel, Subramaniam, Jamuna R., Tessarollo, Lino, Bartnikas, Thomas B., Culotta, Valeria C., Price, Donald L., Rothstein, Jeffrey, Gitlin, Jonathan D., Holtzman, David M., Bales, Kelly R., Tenkova, Tanya, Fagan, Anne M., Parsadanian, Maia, Sartorius, Leah J., Mackey, Brian, Olney, John, McKeel, Daniel, Wozniak, David, Paul, Steven M., Wyttenbach, Andreas, Carmichael, Jenny, Swartz, Jina, Furlong, Robert A., Narain, Yolanda, Rankin, Julia, Rubinsztein, David C., Giannakakou, Paraskevi, Gussio, Rick, Nogales, Eva, Downing, Kenneth H., Zaharevitz, Daniel, Bollbuck, Birgit, Poy, George, Sackett, Dan, Nicolaou, K. C., Fojo, Tito, Ahlijanian, Michael K., Barrezueta, Nestor X., Williams, Robert D., Jakowski, Amy, Kowsz, Kim P., McCarthy, Sheryl, Coskran, Timothy, Carlo, Anthony, Seymour, Patricia A., Burkhardt, John E., Nelson, Robert B., McNeish, John D., Karim-Jimenez, Zoubida, Hernando, Nati, Biber, Jürg, Murer, Heini, Weisinger, R. S., Blair-West, J. R., Burns, P., Denton, D. A., McKinley, M. J., Purcell, B., Vale, W., Rivier, J., Sunagawa, K., Bellamy, Tomas C., Wood, John, Goodwin, David A., Garthwaite, John, Lange, B. Markus, Wildung, Mark R., Stauber, Einar J., Sanchez, Christopher, Pouchnik, Derek, Croteau, Rodney, Kovtun, Yelena, Chiu, Wan-Ling, Tena, Guillaume, Sheen, Jen, Klement, D., Bures, J., Talcott, Joel B., Witton, Caroline, McLean, Maggie F., Hansen, Peter C., Rees, Adrian, Green, Gary G. R., Stein, John F., Eisen, Jonathan A, Heidelberg, John F, White, Owen, Salzberg, Steven L, Berezikov, Eugene, Bucheton, Alain, Busseau, Isabelle, Wolf, Yuri I, Kondrashov, Alexey S, Koonin, Eugene V, Viprey, Virginie, Rosenthal, André, Broughton, William J, Perret, Xavier, Chorin, Alexandre J., Hald, Ole H., Kupferman, Raz
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	The National Academy of Sciences 2000
Assuntos:	Biological Sciences Social Sciences Research Physical Sciences
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC15992/ https://ncbi.nlm.nih.gov/pubmed/10706628 https://ncbi.nlm.nih.gov/pmc/articles/PMC15993/ https://ncbi.nlm.nih.gov/pubmed/10694576 https://ncbi.nlm.nih.gov/pmc/articles/PMC15994/ https://ncbi.nlm.nih.gov/pubmed/10694578 https://ncbi.nlm.nih.gov/pmc/articles/PMC15995/ https://ncbi.nlm.nih.gov/pubmed/10688917 https://ncbi.nlm.nih.gov/pmc/articles/PMC15996/ https://ncbi.nlm.nih.gov/pubmed/10716997 https://ncbi.nlm.nih.gov/pmc/articles/PMC15997/ https://ncbi.nlm.nih.gov/pubmed/10694575 https://ncbi.nlm.nih.gov/pmc/articles/PMC15998/ https://ncbi.nlm.nih.gov/pubmed/10694580 https://ncbi.nlm.nih.gov/pmc/articles/PMC15999/ https://ncbi.nlm.nih.gov/pubmed/10688914 https://ncbi.nlm.nih.gov/pmc/articles/PMC16000/ https://ncbi.nlm.nih.gov/pubmed/10688906 https://ncbi.nlm.nih.gov/pmc/articles/PMC16001/ https://ncbi.nlm.nih.gov/pubmed/10688894 https://ncbi.nlm.nih.gov/pmc/articles/PMC16002/ https://ncbi.nlm.nih.gov/pubmed/10688901 https://ncbi.nlm.nih.gov/pmc/articles/PMC16003/ https://ncbi.nlm.nih.gov/pubmed/10716998 https://ncbi.nlm.nih.gov/pmc/articles/PMC16004/ https://ncbi.nlm.nih.gov/pubmed/10706610 https://ncbi.nlm.nih.gov/pmc/articles/PMC16005/ https://ncbi.nlm.nih.gov/pubmed/10706620 https://ncbi.nlm.nih.gov/pmc/articles/PMC16006/ https://ncbi.nlm.nih.gov/pubmed/10688907 https://ncbi.nlm.nih.gov/pmc/articles/PMC16007/ https://ncbi.nlm.nih.gov/pubmed/10716999 https://ncbi.nlm.nih.gov/pmc/articles/PMC16008/ https://ncbi.nlm.nih.gov/pubmed/10688908 https://ncbi.nlm.nih.gov/pmc/articles/PMC16009/ https://ncbi.nlm.nih.gov/pubmed/10688900 https://ncbi.nlm.nih.gov/pmc/articles/PMC16010/ https://ncbi.nlm.nih.gov/pubmed/10706630 https://ncbi.nlm.nih.gov/pmc/articles/PMC16011/ https://ncbi.nlm.nih.gov/pubmed/10706607 https://ncbi.nlm.nih.gov/pmc/articles/PMC16012/ https://ncbi.nlm.nih.gov/pubmed/10706619 https://ncbi.nlm.nih.gov/pmc/articles/PMC16013/ https://ncbi.nlm.nih.gov/pubmed/10717000 https://ncbi.nlm.nih.gov/pmc/articles/PMC16014/ https://ncbi.nlm.nih.gov/pubmed/10717001 https://ncbi.nlm.nih.gov/pmc/articles/PMC16015/ https://ncbi.nlm.nih.gov/pubmed/10717002 https://ncbi.nlm.nih.gov/pmc/articles/PMC16016/ https://ncbi.nlm.nih.gov/pubmed/10706629 https://ncbi.nlm.nih.gov/pmc/articles/PMC16017/ https://ncbi.nlm.nih.gov/pubmed/10706632 https://ncbi.nlm.nih.gov/pmc/articles/PMC16018/ https://ncbi.nlm.nih.gov/pubmed/10706626 https://ncbi.nlm.nih.gov/pmc/articles/PMC16019/ https://ncbi.nlm.nih.gov/pubmed/10706609 https://ncbi.nlm.nih.gov/pmc/articles/PMC16020/ https://ncbi.nlm.nih.gov/pubmed/10706638 https://ncbi.nlm.nih.gov/pmc/articles/PMC16021/ https://ncbi.nlm.nih.gov/pubmed/10681468 https://ncbi.nlm.nih.gov/pmc/articles/PMC16022/ https://ncbi.nlm.nih.gov/pubmed/10706615 https://ncbi.nlm.nih.gov/pmc/articles/PMC16023/ https://ncbi.nlm.nih.gov/pubmed/10688892 https://ncbi.nlm.nih.gov/pmc/articles/PMC16024/ https://ncbi.nlm.nih.gov/pubmed/10706633 https://ncbi.nlm.nih.gov/pmc/articles/PMC16025/ https://ncbi.nlm.nih.gov/pubmed/10694572 https://ncbi.nlm.nih.gov/pmc/articles/PMC16026/ https://ncbi.nlm.nih.gov/pubmed/10694577 https://ncbi.nlm.nih.gov/pmc/articles/PMC16027/ https://ncbi.nlm.nih.gov/pubmed/10717003 https://ncbi.nlm.nih.gov/pmc/articles/PMC16028/ https://ncbi.nlm.nih.gov/pubmed/10688884 https://ncbi.nlm.nih.gov/pmc/articles/PMC16029/ https://ncbi.nlm.nih.gov/pubmed/10706614 https://ncbi.nlm.nih.gov/pmc/articles/PMC16030/ https://ncbi.nlm.nih.gov/pubmed/10717004 https://ncbi.nlm.nih.gov/pmc/articles/PMC16031/ https://ncbi.nlm.nih.gov/pubmed/10717005 https://ncbi.nlm.nih.gov/pmc/articles/PMC16032/ https://ncbi.nlm.nih.gov/pubmed/10717006 https://ncbi.nlm.nih.gov/pmc/articles/PMC16033/ https://ncbi.nlm.nih.gov/pubmed/10717007 https://ncbi.nlm.nih.gov/pmc/articles/PMC16034/ https://ncbi.nlm.nih.gov/pubmed/10717008 https://ncbi.nlm.nih.gov/pmc/articles/PMC16035/ https://ncbi.nlm.nih.gov/pubmed/10688902 https://ncbi.nlm.nih.gov/pmc/articles/PMC16036/ https://ncbi.nlm.nih.gov/pubmed/10688885 https://ncbi.nlm.nih.gov/pmc/articles/PMC16139/ https://ncbi.nlm.nih.gov/pubmed/11178265 https://ncbi.nlm.nih.gov/pmc/articles/PMC16141/ https://ncbi.nlm.nih.gov/pubmed/11178266 https://ncbi.nlm.nih.gov/pmc/articles/PMC16144/ https://ncbi.nlm.nih.gov/pubmed/11178267 https://ncbi.nlm.nih.gov/pmc/articles/PMC16145/ https://ncbi.nlm.nih.gov/pubmed/11178268 https://ncbi.nlm.nih.gov/pmc/articles/PMC16175/ https://ncbi.nlm.nih.gov/pubmed/10737778
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Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4(+) T cells

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