The Crystal Structure of Shikimate Dehydrogenase (AroE) Reveals a Unique NADPH Binding Mode

Shikimate dehydrogenase catalyzes the NADPH-dependent reversible reduction of 3-dehydroshikimate to shikimate. We report the first X-ray structure of shikimate dehydrogenase from Haemophilus influenzae to 2.4-Å resolution and its complex with NADPH to 1.95-Å resolution. The molecule contains two dom...

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Detalhes bibliográficos
Main Authors: Ye, Sheng, von Delft, Frank, Brooun, Alexei, Knuth, Mark W., Swanson, Ronald V., McRee, Duncan E.
Formato: Artigo
Idioma:en
Publicado em: American Society for Microbiology 2003
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164887/
https://ncbi.nlm.nih.gov/pubmed/12837789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.14.4144-4151.2003
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https://ncbi.nlm.nih.gov/pmc/articles/PMC164887/
https://ncbi.nlm.nih.gov/pubmed/12837789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.185.14.4144-4151.2003

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