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Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones

We have characterized an early series of 5,6-bridged dioxinoquinolones which behaved strikingly different from typical quinolones. The 5,6-bridged dioxinoquinolones inhibited Escherichia coli DNA gyrase supercoiling activity but, unlike typical quinolones, failed to stimulate gyrase-dependent cleava...

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Detalhes bibliográficos
Main Authors:	Macinga, David R., Renick , Paul J., Makin, Kelly M., Ellis, David H., Kreiner, Allison A., Li, Min, Rupnik, Kirk J., Kincaid, Erica M., Wallace, Cynthia D., Ledoussal, Benoit, Morris, Timothy W., Dailey, Charlene F., Pagano, Paul J., Buchanan, Lewis V., Paquette, Jennifer A., Haas, Joseph V., Gibson, John K., Galán, Juan-Carlos, Morosini, María-Isabel, Baquero, María-Rosario, Reig, Milagro, Baquero, Fernando, Jones, Ronald N., Farrell, David J., Morrissey, Ian, Rossi, Jutta, Bischoff, Markus, Wada, Akihito, Berger-Bächi, Brigitte, Murray, Henry W., Brooks, Elaine B., DeVecchio, Jennifer L., Heinzel, Frederick P., Galimand, Marc, Courvalin, Patrice, Lambert, Thierry, Pérez-Victoria, F. Javier, Castanys, Santiago, Gamarro, Francisco, Lin, Chin-Chung, Luu, Kenneth, Lourenco, David, Yeh, Li-Tain, Sanglard, Dominique, Ischer, Françoise, Parkinson, Tania, Falconer, Derek, Bille, Jacques, Huda, Nazmul, Lee, Eun-Woo, Chen, Jing, Morita, Yuji, Kuroda, Teruo, Mizushima, Tohru, Tsuchiya, Tomofusa, Cercenado, Emilia, Cercenado, Sonia, Bouza, Emilio, Zhong, Weidong, An, Haoyun, Barawkar, Dinesh, Hong, Zhi, Beauchef-Havard, Anne, Arlet, Guillaume, Gautier, Valerie, Labia, Roger, Grimont, Patrick, Philippon, Alain, Bermudez, Luiz E., Reynolds, Robert, Kolonoski, Peter, Aralar, Pricilla, Inderlied, Clark B., Young, Lowell S., Nicastri, Emanuele, Sarmati, Loredana, Andreoni, Massimo, G. Parisi, Saverio, Dahl, Kristin H., Sundsfjord, Arnfinn, Biagini, Giancarlo A., Richier, Eric, Bray, Patrick G., Calas, Michèle, Vial, Henri, Ward, Stephen A., Pinjon, Emmanuelle, Moran, Gary P., Jackson, Colin J., Kelly, Steven L., Coleman, David C., Sullivan, Derek J., Werno, Anja M., Anderson, Trevor P., Murdoch, David R., Priebe, Saskia, Schwarz, Stefan, Meshnick, Steven R., Jamieson, Conor E., Lambert, Peter A., Simpson, Iain N., Allen, George P., Kaatz, Glenn W., Rybak, Michael J., Knudsen, Jenny Dahl, Odenholt, Inga, Erlendsdottir, Helga, Gottfredsson, Magnus, Cars, Otto, Frimodt-Møller, Niels, Espersen, Frank, Kristinsson, Karl G., Gudmundsson, Sigurdur, Ciach, Michelle, Zong, Kathleen, Kain, Kevin C., Crandall, Ian, Ueda, Yutaka, Sunagawa, Makoto, Padiglione, Alexander A., Wolfe, Rory, Grabsch, Elizabeth A., Olden, Di, Pearson, Stephen, Franklin, Clare, Spelman, Denis, Mayall, Barrie, Johnson, Paul D. R., Grayson, M. Lindsay, Tsuji, Masakatsu, Takema, Morio, Miwa, Hideaki, Shimada, Jingoro, Kuwahara, Shogo, Pai, Suresh R., Singh, Kavindra V., Murray, Barbara E., Syrogiannopoulos, George A., Grivea, Ioanna N., Ednie, Lois M., Bozdogan, Bülent, Katopodis, George D., Beratis, Nicholas G., Davies, Todd A., Appelbaum, Peter C., Foster, Wendy K., Miller, Darren S., Marion, Patricia L., Colonno, Richard J., Kotlarski, Ieva, Jilbert, Allison R., Spreer, Annette, Kerstan, Holger, Böttcher, Tobias, Gerber, Joachim, Siemer, Alexander, Zysk, Gregor, Mitchell, Timothy J., Eiffert, Helmut, Nau, Roland, O'Keefe, Barry R., Smee, Donald F., Turpin, Jim A., Saucedo, Carrie J., Gustafson, Kirk R., Mori, Toshiyuki, Blakeslee, Dennis, Buckheit, Robert, Boyd, Michael R., Takakura, Natsuko, Wakabayashi, Hiroyuki, Ishibashi, Hiroko, Teraguchi, Susumu, Tamura, Yoshitaka, Yamaguchi, Hideyo, Abe, Shigeru, Ancelin, Marie L., Vidal-Sailhan, Valérie, Herbuté, Serge, Ringwald, Pascal, Vial, Henri J., Bonhoure, Anne, Herbute, Serge, Giamarellos-Bourboulis, Evangelos J., Poulaki, Helen, Kostomitsopoulos, Nikolaos, Dontas, Ismene, Perrea, Despina, Karayannacos, Panayotis E., Giamarellou, Helen, Dunne, Michael W., Khurana, Chandra, Mohs, Adriano Arguedas, Rodriguez, Adib, Arrieta, Antonio, McLinn, Samuel, Krogstad, Judy A., Blatter, Mark, Schwartz, Richard, Vargas, Sergio L., Emparanza, Paz, Fernandez, Pilar, Gooch III, Willis M., Aspin, Mary, Podgore, John, Roine, Irmeli, Blumer, Jeffrey L., Ehrlich, Garth D., Chow, Jean, Rodvold, Keith A., Danziger, Larry H., Gotfried, Mark H., Lycke, Jan, Malmeström, Clas, Ståhle, Lars, Kühn, F., Cottagnoud, M., Acosta, F., Flatz, L., Entenza, J., Cottagnoud, P., Fu, Huamei, Dahlgren, Claes, Bylund, Johan, Mahmoudi, Nassira, Ciceron, Liliane, Franetich, Jean-François, Farhati, Khemais, Silvie, Olivier, Eling, Wijnand, Sauerwein, Robert, Danis, Martin, Mazier, Dominique, Derouin, Francis, Loza, Elena, del Campo, Rosa, Almaraz, Felisa, Cantón, Rafael, Patrzykat, Aleksander, Gallant, Jeffrey W., Seo, Jung-Kil, Pytyck, Jennifer, Douglas, Susan E., Cynamon, Michael H., Sklaney, Mary, Pietrantoni, Agostina, Di Biase, Assunta Maria, Tinari, Antonella, Marchetti, Magda, Valenti, Piera, Seganti, Lucilla, Superti, Fabiana, Arikan, Sevtap, Yurdakul, Pınar, Hascelik, Gulsen, Grutkoski, P. S., Graeber, C. T., Lim, Y. P., Ayala, A., Simms, H. H.
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	American Society for Microbiology 2003
Assuntos:	Mechanisms of Action: Physiological Effects Experimental Therapeutics Mechanisms of Resistance Pharmacology Susceptibility Antiviral Agents Letter to the Editor Clinical Therapeutics Biologic Response Modifiers
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Unique Biological Properties and Molecular Mechanism of 5,6-Bridged Quinolones

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