Down-regulation of p21(WAF1/CIP1) or p27(Kip1) abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

Estrogens and antiestrogens influence the G(1) phase of the cell cycle. In MCF-7 breast cancer cells, estrogen stimulated cell cycle progression through loss of the kinase inhibitor proteins (KIPs) p27 and p21 and through G(1) cyclin-dependent kinase (cdk) activation. Treatment with antiestrogen dru...

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Main Authors: Cariou, Sandrine, Donovan, Jeffrey C. H., Flanagan, W. M., Milic, Andrea, Bhattacharya, Nandita, Slingerland, Joyce M., Orsel, Joke G., Sincock, Paul M., Krise, Jeffrey P., Pfeffer, Suzanne R., Hajra, Leena, Evans, Andrew I., Chen, Mian, Hyduk, Sharon J., Collins, Tucker, Cybulsky, Myron I., Light, Peter E., Bladen, Christopher, Winkfein, Robert J., Walsh, Michael P., French, Robert J., Boettner, Benjamin, Govek, Eve-Ellen, Cross, Justin, Van Aelst, Linda, Massari, Paola, Ho, Yu, Wetzler, Lee M., Yano, Hajime, Uchida, Hiroshi, Iwasaki, Teruo, Mukai, Mutsuko, Akedo, Hitoshi, Nakamura, Kuniaki, Hashimoto, Shigeru, Sabe, Hisataka, Bruick, Richard K., Lommel, Lori, Bucheli, Miriam E., Sweder, Kevin S., Han, Jin-Hua, Lee, Si Hyoung, Tan, Yue-Qing, LeMosy, Ellen K., Hashimoto, Carl, Julien, Bryan, Kaiser, A. Dale, Garza, Anthony, Slukvin, I. I., Lunn, D. P., Watkins, D. I., Golos, T. G., Swenson, William, Wilson, David Sloan, Elias, Roberta, Dynesius, Mats, Jansson, Roland, Ku, Hsin-Mei, Vision, Todd, Liu, Jiping, Tanksley, Steven D., Tanaka, Tetsuya S., Jaradat, Saied A., Lim, Meng K., Kargul, George J., Wang, Xiaohong, Grahovac, Marija J., Pantano, Serafino, Sano, Yuri, Piao, Yulan, Nagaraja, Ramaiah, Doi, Hirofumi, Wood, William H., Becker, Kevin G., Ko, Minoru S. H., Searfoss, Anjanette M., Wickner, Reed B., Flores, Margarita, Mavingui, Patrick, Perret, Xavier, Broughton, William J., Romero, David, Hernández, Georgina, Dávila, Guillermo, Palacios, Rafael, Kokoza, Vladimir, Ahmed, Abduelaziz, Cho, Wen-Long, Jasinskiene, Nijole, James, Anthony A., Raikhel, Alexander, Emery, David W., Yannaki, Evangelia, Tubb, Julie, Stamatoyannopoulos, George, Shu, Hong-Bing, Johnson, Holly, Cota, Manuela, Mengozzi, Manuela, Vicenzi, Elisa, Panina-Bordignon, Paola, Sinigaglia, Francesco, Transidico, Pietro, Sozzani, Silvano, Mantovani, Alberto, Poli, Guido, Borkhardt, Arndt, Bojesen, Stig, Haas, Oskar A., Fuchs, Uta, Bartelheimer, Dominique, Loncarevic, Ivan F., Bohle, Rainer M., Harbott, Jochen, Repp, Reinald, Jaeger, Ulrich, Viehmann, Susanne, Henn, Traudl, Korth, Petra, Scharr, Dirk, Lampert, Fritz, Metcalf, Donald, Di Rago, Ladina, Mifsud, Sandra, Hartley, Lynne, Alexander, Warren S., Benali, Naoual, Cordelier, Pierre, Calise, Denis, Pagès, Philippe, Rochaix, Philippe, Nagy, Attila, Estève, Jean-Pierre, Pour, Parviz M., Schally, Andrew V., Vaysse, Nicole, Susini, Christiane, Buscail, Louis, Tsai, Mindy, Wedemeyer, Jochen, Ganiatsas, Soula, Tam, See-Ying, Zon, Leonard I., Galli, Stephen J., Schechner, Jeffrey S., Nath, Anjali K., Zheng, Lian, Kluger, Martin S., Hughes, Christopher C. W., Sierra-Honigmann, M. Rocio, Lorber, Marc I., Tellides, George, Kashgarian, Michael, Bothwell, Alfred L. M., Pober, Jordan S., Meyer, Thomas, Kneissel, Michaela, Mariani, Jean, Fournier, Brigitte, Koetz, Kerstin, Bryl, Ewa, Spickschen, Kay, O'Fallon, W. Michael, Goronzy, Jörg J., Weyand, Cornelia M., Nagaraju, Kanneboyina, Raben, Nina, Loeffler, Lisa, Parker, Tomasina, Rochon, Paul J., Lee, Eunice, Danning, Carol, Wada, Ryuichi, Thompson, Cynthia, Bahtiyar, Gul, Craft, Joseph, Hooft van Huijsduijnen, Rob, Plotz, Paul, Moos, P. J., Edes, K., Fitzpatrick, F. A., Hu, Zhiwei, Garen, Alan, Phelps, Michael E., Ditzel, Henrik J., Masaki, Yasufumi, Nielsen, Heidi, Farnaes, Lauge, Burton, Dennis R., Saulino, Evan T., Bullitt, Esther, Hultgren, Scott J., Hamoen, Leendert W., Van Werkhoven, Aske F., Venema, Gerard, Dubnau, David, Haan, Keith M., Longnecker, Richard, Späth, Gerald F., Epstein, Linda, Leader, Ben, Singer, Steven M., Avila, Herbert A., Turco, Salvatore J., Beverley, Stephen M., Smith, Bret N., Banfield, Bruce W., Smeraski, Cynthia A., Wilcox, Christine L., Dudek, F. Edward, Enquist, Lynn W., Pickard, Gary E., Ozawa, Clare R., Ho, Jill J., Tsai, David J., Ho, Dora Y., Sapolsky, Robert M., Popken, Gregory J., Bunney, William E., Potkin, Steven G., Jones, Edward G., Ploghaus, Alexander, Tracey, Irene, Clare, Stuart, Gati, Joseph S., Rawlins, J. Nicholas P., Matthews, Paul M., Feng, Jian, Yan, Zhen, Ferreira, Adriana, Tomizawa, Kazuhito, Liauw, Jason A., Zhuo, Min, Allen, Patrick B., Ouimet, Charles C., Greengard, Paul, Hurley, Joyce H., Cahill, Anne L., Currie, Kevin P. M., Fox, Aaron P., Xia, Weiming, Ray, William J., Ostaszewski, Beth L., Rahmati, Talat, Kimberly, W. Taylor, Wolfe, Michael S., Zhang, Jimin, Goate, Alison M., Selkoe, Dennis J., Mascia, Maria Paola, Trudell, James R., Harris, R. Adron, Myung, Chang-Seon, Garrison, James C., Bethin, Kathleen E., Vogt, Sherri K., Muglia, Louis J., Clough, Steven J., Fengler, Kevin A., Yu, I-ching, Lippok, Bernadette, Smith, Roger K., Bent, Andrew F., Birkett, Michael A., Campbell, Colin A. M., Chamberlain, Keith, Guerrieri, Emilio, Hick, Alastair J., Martin, Janet L., Matthes, Michaela, Napier, Johnathan A., Pettersson, Jan, Pickett, John A., Poppy, Guy M., Pow, Eleanor M., Pye, Barry J., Smart, Lesley E., Wadhams, George H., Wadhams, Lester J., Woodcock, Christine M.
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Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC16818/
https://ncbi.nlm.nih.gov/pubmed/10908655
https://ncbi.nlm.nih.gov/pmc/articles/PMC16819/
https://ncbi.nlm.nih.gov/pubmed/10908666
https://ncbi.nlm.nih.gov/pmc/articles/PMC16820/
https://ncbi.nlm.nih.gov/pubmed/10922059
https://ncbi.nlm.nih.gov/pmc/articles/PMC16821/
https://ncbi.nlm.nih.gov/pubmed/10908656
https://ncbi.nlm.nih.gov/pmc/articles/PMC16822/
https://ncbi.nlm.nih.gov/pubmed/10922060
https://ncbi.nlm.nih.gov/pmc/articles/PMC16823/
https://ncbi.nlm.nih.gov/pubmed/10922061
https://ncbi.nlm.nih.gov/pmc/articles/PMC16824/
https://ncbi.nlm.nih.gov/pubmed/10922062
https://ncbi.nlm.nih.gov/pmc/articles/PMC16825/
https://ncbi.nlm.nih.gov/pubmed/10922063
https://ncbi.nlm.nih.gov/pmc/articles/PMC16826/
https://ncbi.nlm.nih.gov/pubmed/10900266
https://ncbi.nlm.nih.gov/pmc/articles/PMC16827/
https://ncbi.nlm.nih.gov/pubmed/10922064
https://ncbi.nlm.nih.gov/pmc/articles/PMC16828/
https://ncbi.nlm.nih.gov/pubmed/10922065
https://ncbi.nlm.nih.gov/pmc/articles/PMC16829/
https://ncbi.nlm.nih.gov/pubmed/10922066
https://ncbi.nlm.nih.gov/pmc/articles/PMC16830/
https://ncbi.nlm.nih.gov/pubmed/10890915
https://ncbi.nlm.nih.gov/pmc/articles/PMC16831/
https://ncbi.nlm.nih.gov/pubmed/10922067
https://ncbi.nlm.nih.gov/pmc/articles/PMC16832/
https://ncbi.nlm.nih.gov/pubmed/10908680
https://ncbi.nlm.nih.gov/pmc/articles/PMC16833/
https://ncbi.nlm.nih.gov/pubmed/10922068
https://ncbi.nlm.nih.gov/pmc/articles/PMC16834/
https://ncbi.nlm.nih.gov/pubmed/10922069
https://ncbi.nlm.nih.gov/pmc/articles/PMC16835/
https://ncbi.nlm.nih.gov/pubmed/10922070
https://ncbi.nlm.nih.gov/pmc/articles/PMC16836/
https://ncbi.nlm.nih.gov/pubmed/10908672
https://ncbi.nlm.nih.gov/pmc/articles/PMC16837/
https://ncbi.nlm.nih.gov/pubmed/10908661
https://ncbi.nlm.nih.gov/pmc/articles/PMC16838/
https://ncbi.nlm.nih.gov/pubmed/10908663
https://ncbi.nlm.nih.gov/pmc/articles/PMC16839/
https://ncbi.nlm.nih.gov/pubmed/10908681
https://ncbi.nlm.nih.gov/pmc/articles/PMC16840/
https://ncbi.nlm.nih.gov/pubmed/10908648
https://ncbi.nlm.nih.gov/pmc/articles/PMC16841/
https://ncbi.nlm.nih.gov/pubmed/10908669
https://ncbi.nlm.nih.gov/pmc/articles/PMC16842/
https://ncbi.nlm.nih.gov/pubmed/10900262
https://ncbi.nlm.nih.gov/pmc/articles/PMC16843/
https://ncbi.nlm.nih.gov/pubmed/10908668
https://ncbi.nlm.nih.gov/pmc/articles/PMC16844/
https://ncbi.nlm.nih.gov/pubmed/10890921
https://ncbi.nlm.nih.gov/pmc/articles/PMC16845/
https://ncbi.nlm.nih.gov/pubmed/10900268
https://ncbi.nlm.nih.gov/pmc/articles/PMC16846/
https://ncbi.nlm.nih.gov/pubmed/10922071
https://ncbi.nlm.nih.gov/pmc/articles/PMC16847/
https://ncbi.nlm.nih.gov/pubmed/10922072
https://ncbi.nlm.nih.gov/pmc/articles/PMC16848/
https://ncbi.nlm.nih.gov/pubmed/10908664
https://ncbi.nlm.nih.gov/pmc/articles/PMC16849/
https://ncbi.nlm.nih.gov/pubmed/10922073
https://ncbi.nlm.nih.gov/pmc/articles/PMC16850/
https://ncbi.nlm.nih.gov/pubmed/10922074
https://ncbi.nlm.nih.gov/pmc/articles/PMC16851/
https://ncbi.nlm.nih.gov/pubmed/10922075
https://ncbi.nlm.nih.gov/pmc/articles/PMC16852/
https://ncbi.nlm.nih.gov/pubmed/10908657
https://ncbi.nlm.nih.gov/pmc/articles/PMC16853/
https://ncbi.nlm.nih.gov/pubmed/10908654
https://ncbi.nlm.nih.gov/pmc/articles/PMC16854/
https://ncbi.nlm.nih.gov/pubmed/10908662
https://ncbi.nlm.nih.gov/pmc/articles/PMC16855/
https://ncbi.nlm.nih.gov/pubmed/10908670
https://ncbi.nlm.nih.gov/pmc/articles/PMC16856/
https://ncbi.nlm.nih.gov/pubmed/10922076
https://ncbi.nlm.nih.gov/pmc/articles/PMC16857/
https://ncbi.nlm.nih.gov/pubmed/10908682
https://ncbi.nlm.nih.gov/pmc/articles/PMC16858/
https://ncbi.nlm.nih.gov/pubmed/10908653
https://ncbi.nlm.nih.gov/pmc/articles/PMC16859/
https://ncbi.nlm.nih.gov/pubmed/10908676
https://ncbi.nlm.nih.gov/pmc/articles/PMC16860/
https://ncbi.nlm.nih.gov/pubmed/10922077
https://ncbi.nlm.nih.gov/pmc/articles/PMC16861/
https://ncbi.nlm.nih.gov/pubmed/10900273
https://ncbi.nlm.nih.gov/pmc/articles/PMC16862/
https://ncbi.nlm.nih.gov/pubmed/10922078
https://ncbi.nlm.nih.gov/pmc/articles/PMC16863/
https://ncbi.nlm.nih.gov/pubmed/10908659
https://ncbi.nlm.nih.gov/pmc/articles/PMC16864/
https://ncbi.nlm.nih.gov/pubmed/10922079
https://ncbi.nlm.nih.gov/pmc/articles/PMC16865/
https://ncbi.nlm.nih.gov/pubmed/10922080
https://ncbi.nlm.nih.gov/pmc/articles/PMC16866/
https://ncbi.nlm.nih.gov/pubmed/10900264
https://ncbi.nlm.nih.gov/pmc/articles/PMC16867/
https://ncbi.nlm.nih.gov/pubmed/10900270
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https://ncbi.nlm.nih.gov/pmc/articles/PMC16818/
https://ncbi.nlm.nih.gov/pubmed/10908655
https://ncbi.nlm.nih.gov/pmc/articles/PMC16819/
https://ncbi.nlm.nih.gov/pubmed/10908666
https://ncbi.nlm.nih.gov/pmc/articles/PMC16820/
https://ncbi.nlm.nih.gov/pubmed/10922059
https://ncbi.nlm.nih.gov/pmc/articles/PMC16821/
https://ncbi.nlm.nih.gov/pubmed/10908656
https://ncbi.nlm.nih.gov/pmc/articles/PMC16822/
https://ncbi.nlm.nih.gov/pubmed/10922060
https://ncbi.nlm.nih.gov/pmc/articles/PMC16823/
https://ncbi.nlm.nih.gov/pubmed/10922061
https://ncbi.nlm.nih.gov/pmc/articles/PMC16824/
https://ncbi.nlm.nih.gov/pubmed/10922062
https://ncbi.nlm.nih.gov/pmc/articles/PMC16825/
https://ncbi.nlm.nih.gov/pubmed/10922063
https://ncbi.nlm.nih.gov/pmc/articles/PMC16826/
https://ncbi.nlm.nih.gov/pubmed/10900266
https://ncbi.nlm.nih.gov/pmc/articles/PMC16827/
https://ncbi.nlm.nih.gov/pubmed/10922064
https://ncbi.nlm.nih.gov/pmc/articles/PMC16828/
https://ncbi.nlm.nih.gov/pubmed/10922065
https://ncbi.nlm.nih.gov/pmc/articles/PMC16829/
https://ncbi.nlm.nih.gov/pubmed/10922066
https://ncbi.nlm.nih.gov/pmc/articles/PMC16830/
https://ncbi.nlm.nih.gov/pubmed/10890915
https://ncbi.nlm.nih.gov/pmc/articles/PMC16831/
https://ncbi.nlm.nih.gov/pubmed/10922067
https://ncbi.nlm.nih.gov/pmc/articles/PMC16832/
https://ncbi.nlm.nih.gov/pubmed/10908680
https://ncbi.nlm.nih.gov/pmc/articles/PMC16833/
https://ncbi.nlm.nih.gov/pubmed/10922068
https://ncbi.nlm.nih.gov/pmc/articles/PMC16834/
https://ncbi.nlm.nih.gov/pubmed/10922069
https://ncbi.nlm.nih.gov/pmc/articles/PMC16835/
https://ncbi.nlm.nih.gov/pubmed/10922070
https://ncbi.nlm.nih.gov/pmc/articles/PMC16836/
https://ncbi.nlm.nih.gov/pubmed/10908672
https://ncbi.nlm.nih.gov/pmc/articles/PMC16837/
https://ncbi.nlm.nih.gov/pubmed/10908661
https://ncbi.nlm.nih.gov/pmc/articles/PMC16838/
https://ncbi.nlm.nih.gov/pubmed/10908663
https://ncbi.nlm.nih.gov/pmc/articles/PMC16839/
https://ncbi.nlm.nih.gov/pubmed/10908681
https://ncbi.nlm.nih.gov/pmc/articles/PMC16840/
https://ncbi.nlm.nih.gov/pubmed/10908648
https://ncbi.nlm.nih.gov/pmc/articles/PMC16841/
https://ncbi.nlm.nih.gov/pubmed/10908669
https://ncbi.nlm.nih.gov/pmc/articles/PMC16842/
https://ncbi.nlm.nih.gov/pubmed/10900262
https://ncbi.nlm.nih.gov/pmc/articles/PMC16843/
https://ncbi.nlm.nih.gov/pubmed/10908668
https://ncbi.nlm.nih.gov/pmc/articles/PMC16844/
https://ncbi.nlm.nih.gov/pubmed/10890921
https://ncbi.nlm.nih.gov/pmc/articles/PMC16845/
https://ncbi.nlm.nih.gov/pubmed/10900268
https://ncbi.nlm.nih.gov/pmc/articles/PMC16846/
https://ncbi.nlm.nih.gov/pubmed/10922071
https://ncbi.nlm.nih.gov/pmc/articles/PMC16847/
https://ncbi.nlm.nih.gov/pubmed/10922072
https://ncbi.nlm.nih.gov/pmc/articles/PMC16848/
https://ncbi.nlm.nih.gov/pubmed/10908664
https://ncbi.nlm.nih.gov/pmc/articles/PMC16849/
https://ncbi.nlm.nih.gov/pubmed/10922073
https://ncbi.nlm.nih.gov/pmc/articles/PMC16850/
https://ncbi.nlm.nih.gov/pubmed/10922074
https://ncbi.nlm.nih.gov/pmc/articles/PMC16851/
https://ncbi.nlm.nih.gov/pubmed/10922075
https://ncbi.nlm.nih.gov/pmc/articles/PMC16852/
https://ncbi.nlm.nih.gov/pubmed/10908657
https://ncbi.nlm.nih.gov/pmc/articles/PMC16853/
https://ncbi.nlm.nih.gov/pubmed/10908654
https://ncbi.nlm.nih.gov/pmc/articles/PMC16854/
https://ncbi.nlm.nih.gov/pubmed/10908662
https://ncbi.nlm.nih.gov/pmc/articles/PMC16855/
https://ncbi.nlm.nih.gov/pubmed/10908670
https://ncbi.nlm.nih.gov/pmc/articles/PMC16856/
https://ncbi.nlm.nih.gov/pubmed/10922076
https://ncbi.nlm.nih.gov/pmc/articles/PMC16857/
https://ncbi.nlm.nih.gov/pubmed/10908682
https://ncbi.nlm.nih.gov/pmc/articles/PMC16858/
https://ncbi.nlm.nih.gov/pubmed/10908653
https://ncbi.nlm.nih.gov/pmc/articles/PMC16859/
https://ncbi.nlm.nih.gov/pubmed/10908676
https://ncbi.nlm.nih.gov/pmc/articles/PMC16860/
https://ncbi.nlm.nih.gov/pubmed/10922077
https://ncbi.nlm.nih.gov/pmc/articles/PMC16861/
https://ncbi.nlm.nih.gov/pubmed/10900273
https://ncbi.nlm.nih.gov/pmc/articles/PMC16862/
https://ncbi.nlm.nih.gov/pubmed/10922078
https://ncbi.nlm.nih.gov/pmc/articles/PMC16863/
https://ncbi.nlm.nih.gov/pubmed/10908659
https://ncbi.nlm.nih.gov/pmc/articles/PMC16864/
https://ncbi.nlm.nih.gov/pubmed/10922079
https://ncbi.nlm.nih.gov/pmc/articles/PMC16865/
https://ncbi.nlm.nih.gov/pubmed/10922080
https://ncbi.nlm.nih.gov/pmc/articles/PMC16866/
https://ncbi.nlm.nih.gov/pubmed/10900264
https://ncbi.nlm.nih.gov/pmc/articles/PMC16867/
https://ncbi.nlm.nih.gov/pubmed/10900270

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