Leflunomide inhibits transendothelial migration of peripheral blood mononuclear cells

Objectives: To test whether the active metabolite of leflunomide (LEF-M), in addition to blocking the proliferation of activated lymphocytes by inhibiting dihydro-orotate dehydrogenase (DHODH), influences the transendothelial migration (TEM) of peripheral blood mononuclear cells (PBMC). Methods: In...

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Main Authors: Grisar, J, Aringer, M, Koller, M, Stummvoll, G, Eselbock, D, Zwolfer, B, Steiner, C, Zierhut, B, Wagner, L, Pietschmann, P, Smolen, J
Formato: Artigo
Idioma:English
Publicado: 2004
Assuntos:
Extended Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1754829/
https://ncbi.nlm.nih.gov/pubmed/15547088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.018440
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1754829/
https://ncbi.nlm.nih.gov/pubmed/15547088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2003.018440

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