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Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer
INTRODUCTION: BRCA1 or BRCA2 germline mutations increase the risk of developing breast cancer. Tumour cells from germline mutation carriers have frequently lost the wild-type allele. This is predicted to result in genomic instability where cell survival depends upon dysfunctional checkpoint mechanis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
BioMed Central
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1779478/ https://ncbi.nlm.nih.gov/pubmed/16846527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1522 |
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