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PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization

Pleckstrin-2 is composed of 2 pleckstrin homology (PH) domains and a disheveled–Egl-10–pleckstrin (DEP) domain. A lipid-binding assay revealed that pleckstrin-2 binds with greatest affinity to D3 and D5 phosphoinositides. Pleckstrin-2 expressed in Jurkat T cells bound to the cellular membrane and en...

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Detalhes bibliográficos
Main Authors: Bach, Tami L., Kerr, Wesley T., Wang, Yanfeng, Bauman, Eve Marie, Kine, Purnima, Whiteman, Eileen L., Morgan, Renell S., Williamson, Edward K., Ostap, E. Michael, Burkhardt, Janis K., Koretzky, Gary A., Birnbaum, Morris J., Abrams, Charles S.
Formato: Artigo
Idioma:English
Publicado em: American Society of Hematology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785144/
https://ncbi.nlm.nih.gov/pubmed/17008542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-001339
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