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Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores
Carboranes represent a potentially rich but underutilized class of inorganic and catabolism-inert pharmacophores. The regioselectivity and ease of derivatization of carboranes allows for facile syntheses of a wide variety of novel structures. The steric bulk, rigidity, and ease of B- and C-derivatiz...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1829220/ https://ncbi.nlm.nih.gov/pubmed/17360344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700316104 |
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