Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation

Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule deficiency in Alzheimer’s disease (AD). However, although this issue is one of the most important aspe...

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Detalhes bibliográficos
Main Authors: Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, Raina, Arun K., Vinters, Harry V., Tabaton, Massimo, Johnson, Anne B., Paula-Barbosa, Manuel, Avíla, Jesus, Jones, Paul K., Castellani, Rudy J., Smith, Mark A., Perry, George
Formato: Artigo
Idioma:English
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851211/
https://ncbi.nlm.nih.gov/pubmed/12707046
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1851211/
https://ncbi.nlm.nih.gov/pubmed/12707046

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