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Induction of Tolerance to Naphthalene in Clara Cells Is Dependent on a Stable Phenotypic Adaptation Favoring Maintenance of the Glutathione Pool

Repeated exposures to the Clara cell cytotoxicant naphthalene (NA) result in target cell populations that become refractory to further injury. To determine whether tolerance occurs from specific adaptations favoring glutathione (GSH) resynthesis without broad shifts in cellular phenotype, mice were...

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Detalhes bibliográficos
Main Authors: West, Jay A. A., Williams, Kurt J., Toskala, Elina, Nishio, Susan J., Fleschner, Chad A., Forman, Henry Jay, Buckpitt, Alan R., Plopper, Charles G.
Formato: Artigo
Idioma:English
Publicado em: American Society for Investigative Pathology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1867174/
https://ncbi.nlm.nih.gov/pubmed/11891208
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