Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivo (19)F magnetic resonance spectroscopy

AIMS: To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo (19)F magnetic resonance spectroscopy (MRS). METHODS: Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(−1) for 5 days using a (1)H/(19)F surfa...

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Detalhes bibliográficos
Main Authors: Payne, Geoffrey S, Collins, David J, Loynds, Peter, Mould, Graham, Murphy, Philip S, Dzik-Jurasz, Andrzej S K, Kessar, Preminda, Haque, Nazneen, Yamaguchi, Masayuki, Atarashi, Shogo, Leach, Martin O
Formato: Artigo
Idioma:English
Publicado em: Blackwell Science Inc 2005
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Short Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884756/
https://ncbi.nlm.nih.gov/pubmed/15676049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02246.x
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1884756/
https://ncbi.nlm.nih.gov/pubmed/15676049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2004.02246.x

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