The B″/PR72 subunit mediates Ca(2+)-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A

In dopaminoceptive neurons, dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) plays a central role in integrating the effects of dopamine and other neurotransmitters. Phosphorylation of DARPP-32 at Thr-34 by protein kinase A results in inhibition of protein phosphatase 1 (PP1), and ph...

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Autores principales: Ahn, Jung-Hyuck, Sung, Jee Young, McAvoy, Thomas, Nishi, Akinori, Janssens, Veerle, Goris, Jozef, Greengard, Paul, Nairn, Angus C.
Formato: Artículo
Lenguaje:English
Publicado: National Academy of Sciences 2007
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1887582/
https://ncbi.nlm.nih.gov/pubmed/17535922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703589104
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1887582/
https://ncbi.nlm.nih.gov/pubmed/17535922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703589104

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