Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

BACKGROUND: Persistent infection in resting CD4+ Tcells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains latency of integrated HIV, we tested the ability of the HDAC inhibitor valproic acid to deplete persistent, latent infection in resting...

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Detalhes bibliográficos
Main Authors: Lehrman, Ginger, Hogue, Ian B, Palmer, Sarah, Jennings, Cheryl, Spina, Celsa A, Wiegand, Ann, Landay, Alan L, Coombs, Robert W, Richman, Douglas D, Mellors, John W, Coffin, John M, Bosch, Ronald J, Margolis, David M
Formato: Artigo
Idioma:English
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894952/
https://ncbi.nlm.nih.gov/pubmed/16099290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(05)67098-5
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1894952/
https://ncbi.nlm.nih.gov/pubmed/16099290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(05)67098-5

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