CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53

Intravenous infusion of autologous chronic lymphocytic leukemia (CLL) cells transduced with an adenovirus encoding CD40-ligand (CD154) caused rapid reductions in leukemia-cell counts and lymphnode size. We hypothesized that CD40-ligation via CD154 sensitized CLL cells to death-receptor-mediated apop...

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Detalhes bibliográficos
Main Authors: Dicker, Frank, Kater, Arnon P., Prada, Carlos E., Fukuda, Tetsuya, Castro, Januario E., Sun, Guizhen, Wang, Jean Y., Kipps, Thomas J.
Formato: Artigo
Idioma:English
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895435/
https://ncbi.nlm.nih.gov/pubmed/16741250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017749
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1895435/
https://ncbi.nlm.nih.gov/pubmed/16741250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017749

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