CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53

Intravenous infusion of autologous chronic lymphocytic leukemia (CLL) cells transduced with an adenovirus encoding CD40-ligand (CD154) caused rapid reductions in leukemia-cell counts and lymphnode size. We hypothesized that CD40-ligation via CD154 sensitized CLL cells to death-receptor-mediated apop...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Dicker, Frank, Kater, Arnon P., Prada, Carlos E., Fukuda, Tetsuya, Castro, Januario E., Sun, Guizhen, Wang, Jean Y., Kipps, Thomas J.
Natura: Articolo
Lingua:English
Pubblicazione: © 2006 by The American Society of Hematology 2006
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895435/
https://ncbi.nlm.nih.gov/pubmed/16741250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017749
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Accesso online

https://ncbi.nlm.nih.gov/pmc/articles/PMC1895435/
https://ncbi.nlm.nih.gov/pubmed/16741250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-04-017749

Documenti analoghi