ESAT-6 from Mycobacterium tuberculosis Dissociates from Its Putative Chaperone CFP-10 under Acidic Conditions and Exhibits Membrane-Lysing Activity

The 6-kDa early secreted antigenic target ESAT-6 and the 10-kDa culture filtrate protein CFP-10 of Mycobacterium tuberculosis are secreted by the ESX-1 system into the host cell and thereby contribute to pathogenicity. Although different studies performed at the organismal and cellular levels have h...

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Detalhes bibliográficos
Main Authors: de Jonge, Marien I., Pehau-Arnaudet, Gérard, Fretz, Marjan M., Romain, Felix, Bottai, Daria, Brodin, Priscille, Honoré, Nadine, Marchal, Gilles, Jiskoot, Wim, England, Patrick, Cole, Stewart T., Brosch, Roland
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology 2007
Assuntos:
Molecular Biology of Pathogens
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952024/
https://ncbi.nlm.nih.gov/pubmed/17557817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00469-07
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https://ncbi.nlm.nih.gov/pmc/articles/PMC1952024/
https://ncbi.nlm.nih.gov/pubmed/17557817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00469-07

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