Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes

We identified a childhood obesity locus on chromosome 6q16.3-q24.21 that includes 2.4 Mb common to eight genome scans for Type 2 diabetes (T2D) or obesity1-8. Analysis of the ENPP1 (PC-1) gene, a candidate for insulin resistance9,10 in 6,147 subjects revealed association between a three allele risk...

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Main Authors:	Meyre, David, Bouatia-Naji, Nabila, Tounian, Agnès, Samson, Chantal, Lecoeur, Cécile, Vatin, Vincent, Ghoussaini, Maya, Wachter, Christophe, Hercberg, Serge, Charpentier, Guillaume, Patsch, Wolfgang, Pattou, François, Charles, Marie-Aline, Tounian, Patrick, Clément, Karine, Jouret, Béatrice, Weill, Jacques, Maddux, Betty A., Goldfine, Ira D., Walley, Andrew, Boutin, Philippe, Dina, Christian, Froguel, Philippe
Formato:	Artigo
Idioma:	English
Publicado em:	2005
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2000804/ https://ncbi.nlm.nih.gov/pubmed/16025115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1604
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