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Synthesis and Cytotoxicity of Desmethoxycallipeltin B. Lack of a Quinone Methide for the Cytotoxicity of Callipeltin B
The desmethoxy analogue of the cytotoxic, cyclic depsipeptide callipeltin B was synthesized to evaluate the role of its β-MeOTyr residue. The IC(50) of desmethoxycallipeltin B, in which the β-MeOTyr residue was replaced by D-Tyr, against HeLa cells was found to be 128±10 µM in an MTT assay, compared...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2013933/ https://ncbi.nlm.nih.gov/pubmed/17643303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.07.003 |
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