Retrovirus silencer blocking by the cHS4 insulator is CTCF independent

Silencing of retrovirus vectors poses a significant obstacle to genetic manipulation of stem cells and their use in gene therapy. We describe a mammalian silencer blocking assay using insulator elements positioned between retrovirus silencer elements and an LCRβ-globin reporter transgene. In transge...

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Main Authors: Yao, Shuyuan, Osborne, Cameron S., Bharadwaj, Rikki R., Pasceri, Peter, Sukonnik, Tanya, Pannell, Dylan, Recillas-Targa, Félix, West, Adam G., Ellis, James
Formato: Artigo
Idioma:en
Publicado em: Oxford University Press 2003
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC203325/
https://ncbi.nlm.nih.gov/pubmed/12954767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg742
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https://ncbi.nlm.nih.gov/pmc/articles/PMC203325/
https://ncbi.nlm.nih.gov/pubmed/12954767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg742

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