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HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture

Through a functional genomic screen for mitotic regulators, we identified hepatoma up-regulated protein (HURP) as a protein that is required for chromosome congression and alignment. In HURP-depleted cells, the persistence of unaligned chromosomes and the reduction of tension across sister kinetocho...

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Detalhes bibliográficos
Main Authors: Wong, Jim, Fang, Guowei
Formato: Artigo
Idioma:English
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063914/
https://ncbi.nlm.nih.gov/pubmed/16769820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200511132
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