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A “knockdown” mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

The hematopoietic-restricted transcription factor GATA-1 is required for both mammalian erythroid cell and megakaryocyte differentiation. To define the mechanisms governing its transcriptional regulation, we replaced upstream sequences including a DNase I hypersensitive (HS) region with a neomycin-r...

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Detalhes bibliográficos
Main Authors:	McDevitt, Michael A., Shivdasani, Ramesh A., Fujiwara, Yuko, Yang, Haidi, Orkin, Stuart H., Golenda, Claudia F., Li, Jun, Rosenberg, Ronald, Rossini, Carmen, Attygalle, Athula B., González, Andrés, Smedley, Scott R., Eisner, Maria, Meinwald, Jerrold, Eisner, Thomas, Martínez, Miguel A., Verdaguer, Nuria, Mateu, Mauricio G., Domingo, Esteban, Escriva, Hector, Safi, Rachid, Hänni, Catherine, Langlois, Marie-Claire, Saumitou-Laprade, Pierre, Stehelin, Dominique, Capron, André, Pierce, Raymond, Laudet, Vincent, Gaut, Brandon S., Doebley, John F., Strimmer, Korbinian, von Haeseler, Arndt, Rzhetsky, Andrey, Ayala, Francisco José, Hsu, Lily C., Chang, Cheng, Yoshida, Akira, Roner, Michael R., Nepliouev, Igor, Sherry, Barbara, Joklik, Wolfgang K., Lavery, Daniel J., Lopez-Molina, Luis, Fleury-Olela, Fabienne, Schibler, Ueli, Ahrens, Constanze, Grewe, Markus, Berneburg, Mark, Grether-Beck, Susanne, Quilliet, Xavier, Mezzina, Mauro, Sarasin, Alain, Lehmann, Alan R., Arlett, Colin F., Krutmann, Jean, Mbikay, Majambu, Tadros, Haidy, Ishida, Norito, Lerner, Charlie P., De Lamirande, Eve, Chen, Andrew, El-Alfy, Mohamed, Clermont, Yves, Seidah, Nabil G., Chrétien, Michel, Gagnon, Claude, Simpson, Elizabeth M., Smith, Jane, Modrich, Paul, Leung, W.-Y., Malkova, A., Haber, J. E., Barakat, Abdelali, Carels, Nicolas, Bernardi, Giorgio, Yu, Jingwei, Tong, Suhong, Shen, Yiping, Kao, Fa-Ten, Anderson, Lorinda K., Offenberg, Hildo H., Verkuijlen, W. M. H. C., Heyting, Christa, Planz, Oliver, Ehl, Stephan, Furrer, Esther, Horvath, Edit, Bründler, Marie-Anne, Hengartner, Hans, Zinkernagel, Rolf M., Balendiran, Ganesaratnam K., Solheim, Joyce C., Young, Aideen C. M., Hansen, Ted H., Nathenson, Stanley G., Sacchettini, James C., Armstrong, Todd D., Clements, Virginia K., Martin, Brian K., Ting, Jenny P.-Y., Ostrand-Rosenberg, Suzanne, Lavoie, Pascal M., Thibodeau, Jacques, Cloutier, Isabelle, Busch, Robert, Sékaly, Rafick-P., Hänninen, Arno, Jaakkola, Ilkka, Salmi, Marko, Simell, Olli, Jalkanen, Sirpa, Lehner, Paul J., Karttunen, Jaana T., Wilkinson, Gavin W. G., Cresswell, Peter, Chen, Min, Cheng, Alan, Chen, Yi-Qing, Hymel, Anka, Hanson, Eric P., Kimmel, Lida, Minami, Yasuhiro, Taniguchi, Tadatsugu, Changelian, Paul S., O’Shea, John J., Flannery, John G., Zolotukhin, Sergei, Vaquero, M. Isabel, LaVail, Matthew M., Muzyczka, Nicholas, Hauswirth, William W., Toomey, John R., Kratzer, Kenneth E., Lasky, Nina M., Broze, George J., Mizuta, Ryushin, LaSalle, Janine M., Cheng, Hwei-Ling, Shinohara, Akira, Ogawa, Hideyuki, Copeland, Neal, Jenkins, Nancy A., Lalande, Marc, Alt, Frederick W., Helin, Kristian, Holm, Karin, Niebuhr, Anita, Eiberg, Hans, Tommerup, Niels, Hougaard, Susanne, Poulsen, Hans Skovgaard, Spang-Thomsen, Mogens, Nørgaard, Peter, Kharbanda, Surender, Pandey, Pramod, Schofield, Lesley, Israels, Sara, Roncinske, Richard, Yoshida, Kiyotsugu, Bharti, Ajit, Yuan, Zhi-Min, Saxena, Satya, Weichselbaum, Ralph, Nalin, Carlo, Kufe, Donald, Watanabe, Hideto, Nakata, Ken, Kimata, Koji, Nakanishi, Isao, Yamada, Yoshihiko, Zhao, Nanding, Stoffel, Archontoula, Wang, Pauline W., Eisenbart, James D., Espinosa, Rafael, Larson, Richard A., Le Beau, Michelle M., Xia, Yong, Zweier, Jay L., Hofer, Anders, Schmidt, Peter P., Gräslund, Astrid, Thelander, Lars, Tsiokas, Leonidas, Kim, Emily, Arnould, Thierry, Sukhatme, Vikas P., Walz, Gerd, Bonhoeffer, Sebastian, May, Robert M., Shaw, George M., Nowak, Martin A., Wang, Ping, Granados, Robert R., Xie, Xiaping, Liaw, Jim-Shih, Baudry, Michel, Berger, Theodore W., Hyder, Fahmeed, Phelps, Elizabeth A., Wiggins, Christopher J., Labar, Kevin S., Blamire, Andrew M., Shulman, Robert G., Paysan, Jacques, Kossel, Albrecht, Bolz, Jürgen, Fritschy, Jean-Marc, Fei, Hong, Okano, Hirotaka J., Li, Cai, Lee, Gwo-Hwa, Zhao, Connie, Darnell, Robert, Friedman, Jeffrey M., Reichling, David B., Levine, Jon D., Xiong, Z.-G., Lu, W.-Y., MacDonald, J. F., Creedon, Douglas J., Tansey, Malú G., Baloh, Robert H., Osborne, Patricia A., Lampe, Patricia A., Fahrner, Timothy J., Heuckeroth, Robert O., Milbrandt, Jeffrey, Johnson, Eugene M., Gorovits, Rena, Avidan, Nili, Avisar, Noa, Shaked, Iftach, Vardimon, Lily, Castellani, Valerie, Charpier, S., Deniau, J. M., Bernabeu, Ramon, Bevilaqua, Lia, Ardenghi, Patricia, Bromberg, Elke, Schmitz, Paulo, Bianchin, Marino, Izquierdo, Ivan, Medina, Jorge H., Ray, Jasodhara, Baird, Andrew, Gage, Fred H., Impagnatiello, F., Oberto, A., Longone, P., Costa, E., Guidotti, A., de Miera, Eleazar Vega-Saenz, Rudy, Bernardo, Sugimori, Mutsuyuki, Llinás, Rodolfo
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	The National Academy of Sciences of the USA 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC21235/ https://ncbi.nlm.nih.gov/pubmed/9192642 https://ncbi.nlm.nih.gov/pmc/articles/PMC21236/ https://ncbi.nlm.nih.gov/pubmed/9192643 https://ncbi.nlm.nih.gov/pmc/articles/PMC21237/ https://ncbi.nlm.nih.gov/pubmed/9192644 https://ncbi.nlm.nih.gov/pmc/articles/PMC21238/ https://ncbi.nlm.nih.gov/pubmed/9192645 https://ncbi.nlm.nih.gov/pmc/articles/PMC21239/ https://ncbi.nlm.nih.gov/pubmed/9192646 https://ncbi.nlm.nih.gov/pmc/articles/PMC21240/ https://ncbi.nlm.nih.gov/pubmed/11038553 https://ncbi.nlm.nih.gov/pmc/articles/PMC21241/ https://ncbi.nlm.nih.gov/pubmed/9192648 https://ncbi.nlm.nih.gov/pmc/articles/PMC21242/ https://ncbi.nlm.nih.gov/pubmed/9192649 https://ncbi.nlm.nih.gov/pmc/articles/PMC21243/ https://ncbi.nlm.nih.gov/pubmed/9192650 https://ncbi.nlm.nih.gov/pmc/articles/PMC21244/ https://ncbi.nlm.nih.gov/pubmed/9192651 https://ncbi.nlm.nih.gov/pmc/articles/PMC21245/ https://ncbi.nlm.nih.gov/pubmed/9192652 https://ncbi.nlm.nih.gov/pmc/articles/PMC21246/ https://ncbi.nlm.nih.gov/pubmed/9192653 https://ncbi.nlm.nih.gov/pmc/articles/PMC21247/ https://ncbi.nlm.nih.gov/pubmed/9192654 https://ncbi.nlm.nih.gov/pmc/articles/PMC21248/ https://ncbi.nlm.nih.gov/pubmed/9192655 https://ncbi.nlm.nih.gov/pmc/articles/PMC21249/ https://ncbi.nlm.nih.gov/pubmed/9192656 https://ncbi.nlm.nih.gov/pmc/articles/PMC21250/ https://ncbi.nlm.nih.gov/pubmed/9192657 https://ncbi.nlm.nih.gov/pmc/articles/PMC21251/ https://ncbi.nlm.nih.gov/pubmed/11038554 https://ncbi.nlm.nih.gov/pmc/articles/PMC21252/ https://ncbi.nlm.nih.gov/pubmed/9192659 https://ncbi.nlm.nih.gov/pmc/articles/PMC21253/ https://ncbi.nlm.nih.gov/pubmed/9192660 https://ncbi.nlm.nih.gov/pmc/articles/PMC21254/ https://ncbi.nlm.nih.gov/pubmed/9192661 https://ncbi.nlm.nih.gov/pmc/articles/PMC21255/ https://ncbi.nlm.nih.gov/pubmed/9192662 https://ncbi.nlm.nih.gov/pmc/articles/PMC21256/ https://ncbi.nlm.nih.gov/pubmed/9192663 https://ncbi.nlm.nih.gov/pmc/articles/PMC21257/ https://ncbi.nlm.nih.gov/pubmed/9192664 https://ncbi.nlm.nih.gov/pmc/articles/PMC21258/ https://ncbi.nlm.nih.gov/pubmed/9192665 https://ncbi.nlm.nih.gov/pmc/articles/PMC21259/ https://ncbi.nlm.nih.gov/pubmed/9192666 https://ncbi.nlm.nih.gov/pmc/articles/PMC21260/ https://ncbi.nlm.nih.gov/pubmed/9192667 https://ncbi.nlm.nih.gov/pmc/articles/PMC21261/ https://ncbi.nlm.nih.gov/pubmed/9192668 https://ncbi.nlm.nih.gov/pmc/articles/PMC21262/ https://ncbi.nlm.nih.gov/pubmed/9192669 https://ncbi.nlm.nih.gov/pmc/articles/PMC21263/ https://ncbi.nlm.nih.gov/pubmed/9192670 https://ncbi.nlm.nih.gov/pmc/articles/PMC21264/ https://ncbi.nlm.nih.gov/pubmed/9192671 https://ncbi.nlm.nih.gov/pmc/articles/PMC21265/ https://ncbi.nlm.nih.gov/pubmed/9192672 https://ncbi.nlm.nih.gov/pmc/articles/PMC21266/ https://ncbi.nlm.nih.gov/pubmed/9192673 https://ncbi.nlm.nih.gov/pmc/articles/PMC21267/ https://ncbi.nlm.nih.gov/pubmed/9192674 https://ncbi.nlm.nih.gov/pmc/articles/PMC21268/ https://ncbi.nlm.nih.gov/pubmed/9192675 https://ncbi.nlm.nih.gov/pmc/articles/PMC21269/ https://ncbi.nlm.nih.gov/pubmed/9192676 https://ncbi.nlm.nih.gov/pmc/articles/PMC21270/ https://ncbi.nlm.nih.gov/pubmed/9192677 https://ncbi.nlm.nih.gov/pmc/articles/PMC21271/ https://ncbi.nlm.nih.gov/pubmed/9192678 https://ncbi.nlm.nih.gov/pmc/articles/PMC21272/ https://ncbi.nlm.nih.gov/pubmed/9192679 https://ncbi.nlm.nih.gov/pmc/articles/PMC21273/ https://ncbi.nlm.nih.gov/pubmed/9192680 https://ncbi.nlm.nih.gov/pmc/articles/PMC21274/ https://ncbi.nlm.nih.gov/pubmed/9192681 https://ncbi.nlm.nih.gov/pmc/articles/PMC21275/ https://ncbi.nlm.nih.gov/pubmed/9192682 https://ncbi.nlm.nih.gov/pmc/articles/PMC21276/ https://ncbi.nlm.nih.gov/pubmed/9192683 https://ncbi.nlm.nih.gov/pmc/articles/PMC21277/ https://ncbi.nlm.nih.gov/pubmed/9192684 https://ncbi.nlm.nih.gov/pmc/articles/PMC21278/ https://ncbi.nlm.nih.gov/pubmed/9192685 https://ncbi.nlm.nih.gov/pmc/articles/PMC21279/ https://ncbi.nlm.nih.gov/pubmed/9192686 https://ncbi.nlm.nih.gov/pmc/articles/PMC21280/ https://ncbi.nlm.nih.gov/pubmed/9192687 https://ncbi.nlm.nih.gov/pmc/articles/PMC21281/ https://ncbi.nlm.nih.gov/pubmed/9192688 https://ncbi.nlm.nih.gov/pmc/articles/PMC21282/ https://ncbi.nlm.nih.gov/pubmed/9192689 https://ncbi.nlm.nih.gov/pmc/articles/PMC21283/ https://ncbi.nlm.nih.gov/pubmed/9192690 https://ncbi.nlm.nih.gov/pmc/articles/PMC21284/ https://ncbi.nlm.nih.gov/pubmed/9192691
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A “knockdown” mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

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