Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities

Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP(3)) receptors (IP(3)Rs), ryanodine receptors, and TRP channels. However, their role in Ca(2+) signaling in vivo is not known. Characterization of Ca(2+) signaling in pancreatic acinar cells...

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Main Authors: Shin, Dong Min, Dehoff, Marlin, Luo, Xiang, Kang, Shin Hyeok, Tu, Jiangchen, Nayak, Surendra K., Ross, Elliott M., Worley, Paul F., Muallem, Shmuel
Formato: Artigo
Idioma:English
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172804/
https://ncbi.nlm.nih.gov/pubmed/12860966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210109
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2172804/
https://ncbi.nlm.nih.gov/pubmed/12860966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210109

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