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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
Cleavage of amyloid precursor protein (APP) by the Alzheimer's β-secretase (BACE1) is a key step in generating amyloid β-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with β-site APP-cleaving enzyme (BACE) 1 and regulates its cleavag...
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| Hlavní autoři: | , , , , , |
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| Médium: | Článek |
| Jazyk: | English |
| Vydáno: |
The Rockefeller University Press
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173449/ https://ncbi.nlm.nih.gov/pubmed/14530380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200303059 |
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