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Crystal structure of human type II inosine monophosphate dehydrogenase: Implications for ligand binding and drug design

Inosine monophosphate dehydrogenase (IMPDH) controls a key metabolic step in the regulation of cell growth and differentiation. This step is the NAD-dependent oxidation of inosine 5′ monophosphate (IMP) to xanthosine 5′ monophosphate, the rate-limiting step in the synthesis of the guanine nucleotide...

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Detalhes bibliográficos
Main Authors: Colby, Thomas D., Vanderveen, Kristen, Strickler, Michael D., Markham, George D., Goldstein, Barry M.
Formato: Artigo
Idioma:en
Publicado em: The National Academy of Sciences 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22327/
https://ncbi.nlm.nih.gov/pubmed/10097070
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