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Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by proteolysis of its inhibitory subunit (IκB) via the ubiquitin-proteasome pathway. Signal-induced phosphorylation of IκBα by a large multisubunit complex containing IκB kinases is a prerequisite for ubiquitination....

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Prif Awduron:	Hatakeyama, Shigetsugu, Kitagawa, Masatoshi, Nakayama, Keiko, Shirane, Michiko, Matsumoto, Masaki, Hattori, Kimihiko, Higashi, Hideaki, Nakano, Hiroyasu, Okumura, Ko, Onoé, Kazunori, Good, Robert A., Nakayama, Kei-ichi, Snyder, Greg A., Brooks, Andrew G., Sun, Peter D., Schatzle, John D., Sheu, Shane, Stepp, Susan E., Mathew, Porunelloor A., Bennett, Michael, Kumar, Vinay, Li, Runzhao, Pei, Huiping, Papas, Takis, Biro, Judit, Würch, Andreas, Potocnik, Alexandre J., Falk, Ingrid, Mossmann, Horst, Eichmann, Klaus, Ouyang, Wenjun, Jacobson, Nils G., Bhattacharya, Deepta, Gorham, James D., Fenoglio, Domenic, Sha, William C., Murphy, Theresa L., Murphy, Kenneth M., Kaufman, Marcelle, Andris, Fabienne, Leo, Oberdan, Rao, Vallabhaneni V., Dahlheimer, Julie L., Bardgett, Mark E., Snyder, Abraham Z., Finch, Rick A., Sartorelli, Alan C., Piwnica-Worms, David, Wang, Lili, Takabe, Kazuaki, Bidlingmaier, Scott M., Ill, Charles R., Verma, Inder M., Toft, Neil J., Winton, Douglas J., Kelly, Jane, Howard, Louise A., Dekker, Marleen, te Riele, Hein, Arends, Mark J., Wyllie, Andrew H., Margison, Geoffrey P., Clarke, Alan R., Nikitin, Alexander Yu., Juárez-Pérez, María I., Li, Song, Huang, Leaf, Lee, Wen-Hwa, Lammich, Sven, Kojro, Elzbieta, Postina, Rolf, Gilbert, Sandra, Pfeiffer, Roland, Jasionowski, Marek, Haass, Christian, Fahrenholz, Falk, Ishii, Hideshi, Baffa, Raffaele, Numata, Shin-Ichiro, Murakumo, Yoshiki, Rattan, Shashi, Inoue, Hiroshi, Mori, Masaki, Fidanza, Vincenzo, Alder, Hansjuerg, Croce, Carlo M., Tsiokas, Leonidas, Arnould, Thierry, Zhu, Chenwen, Kim, Emily, Walz, Gerd, Sukhatme, Vikas P., Felsher, Dean W., Bishop, J. Michael, Iaccarino, Guido, Smithwick, L. Ashley, Lefkowitz, Robert J., Koch, Walter J., Demetri, George D., Fletcher, Christopher D. M., Mueller, Elisabetta, Sarraf, Pasha, Naujoks, Ryan, Campbell, Natalee, Spiegelman, Bruce M., Singer, Samuel, Baluna, Roxana, Rizo, Josep, Gordon, Brian E., Ghetie, Victor, Vitetta, Ellen S., Zhang, Zhongjian, Kundu, Gopal C., Panda, Dibyendu, Mandal, Asim K., Mantile-Selvaggi, Giuditta, Peri, Alessandro, Yuan, Chiun-Jye, Mukherjee, Anil B., Bellacosa, Alfonso, Cicchillitti, Lucia, Schepis, Filippo, Riccio, Antonio, Yeung, Anthony T., Matsumoto, Yoshihiro, Golemis, Erica A., Genuardi, Maurizio, Neri, Giovanni, Schinke, Martina, Baltatu, Ovidiu, Böhm, Manfred, Peters, Jörg, Rascher, Wolfgang, Bricca, Giampiero, Lippoldt, Andrea, Ganten, Detlev, Bader, Michael, Lee, Brendan, Dennis, Julie A., Healy, Peter J., Mull, Benjamin, Pastore, Lucio, Yu, Hung, Aguilar-Cordova, Estuardo, O’Brien, William, Reeds, Peter, Beaudet, Arthur L., Raeber, Alex J., Sailer, Andreas, Hegyi, Ivan, Klein, Michael A., Rülicke, Thomas, Fischer, Marek, Brandner, Sebastian, Aguzzi, Adriano, Weissmann, Charles, Inoue, Kazushi, Roussel, Martine F., Sherr, Charles J., Paige, Lisa A., Christensen, Dale J., Grøn, Hanne, Norris, John D., Gottlin, Elizabeth B., Padilla, Karen M., Chang, Ching-yi, Ballas, Lawrence M., Hamilton, Paul T., McDonnell, Donald P., Fowlkes, Dana M., Zhao, Yi, Zhu, Lunjian, Lee, Sunyoung, Li, Ling, Chang, Eric, Soong, Nay-Wei, Douer, Dan, Anderson, W. French, Liu, Jun, Nikaido, Hiroshi, Pujol, Céline, Eugène, Emmanuel, Marceau, Michaël, Nassif, Xavier, Finkel, Steven E., Kolter, Roberto, Yildiz, Fitnat H., Schoolnik, Gary K., Strange, B. A., Fletcher, P. C., Henson, R. N. A., Friston, K. J., Dolan, R. J., Touhara, Kazushige, Sengoku, Shintaro, Inaki, Koichiro, Tsuboi, Akio, Hirono, Junzo, Sato, Takaaki, Sakano, Hitoshi, Haga, Tatsuya, Bons, Nöelle, Mestre-Frances, Nadine, Belli, Patrick, Cathala, Françoise, Gajdusek, D. Carleton, Brown, Paul, Li, Chao-Yi, Lei, Jing-Jiang, Yao, Hai-Shan, Vnek, Norbert, Ramsden, Benjamin M., Hung, Chou P., Goldman-Rakic, Patricia S., Roe, Anna Wang, Reyes-Harde, Magali, Empson, Ruth, Potter, Barry V. L., Galione, Antony, Stanton, Patric K., Debeir, Thomas, Saragovi, H. Uri, Cuello, A. Claudio, Gao, Pan-Pan, Yue, Yong, Cerretti, Douglas Pat, Dreyfus, Cheryl, Zhou, Renping, Yamada, Masanobu, Oligino, Thomas, Mata, Marina, Goss, James R., Glorioso, Joseph C., Fink, David J., Löwenheim, Hubert, Furness, David N., Kil, Jonathan, Zinn, Christoph, Gültig, Karina, Fero, Matthew L., Frost, Deanna, Gummer, Anthony W., Roberts, James M., Rubel, Edwin W., Hackney, Carole M., Zenner, Hans-Peter, Zhang, Su-Chun, Ge, Bin, Duncan, Ian D., Chang, Sunghoe, Popov, Sergey V., Van Goor, Fredrick, Krsmanovic, Lazar Z., Catt, Kevin J., Stojilkovic, Stanko S., Schikorski, T., Stevens, C. F., García-Colunga, Jesús, Miledi, Ricardo, Ancolio, K., Dumanchin, C., Barelli, H., Warter, J. M., Brice, A., Campion, D., Frébourg, T., Checler, F., Guo, Qing, Sebastian, Lois, Sopher, Bryce L., Miller, Miles W., Glazner, Gordon W., Ware, Carol B., Martin, George M., Mattson, Mark P., Takagi, Yasushi, Mitsui, Akira, Nishiyama, Akira, Nozaki, Kazuhiko, Sono, Hiroshi, Gon, Yasuhiro, Hashimoto, Nobuo, Yodoi, Junji, Wallner, Martin, Meera, Pratap, Toro, Ligia, Gozes, I., Perl, O., Giladi, E., Davidson, A., Ashur-Fabian, O., Rubinraut, S., Fridkin, M.
Fformat:	Erthygl
Iaith:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Cyhoeddwyd:	The National Academy of Sciences 1999
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.gov/pmc/articles/PMC22385/ https://ncbi.nlm.nih.gov/pubmed/10097128 https://ncbi.nlm.nih.gov/pmc/articles/PMC22386/ https://ncbi.nlm.nih.gov/pubmed/10097129 https://ncbi.nlm.nih.gov/pmc/articles/PMC22387/ https://ncbi.nlm.nih.gov/pubmed/10097130 https://ncbi.nlm.nih.gov/pmc/articles/PMC22388/ https://ncbi.nlm.nih.gov/pubmed/10097131 https://ncbi.nlm.nih.gov/pmc/articles/PMC22389/ https://ncbi.nlm.nih.gov/pubmed/10097132 https://ncbi.nlm.nih.gov/pmc/articles/PMC22390/ https://ncbi.nlm.nih.gov/pubmed/10097133 https://ncbi.nlm.nih.gov/pmc/articles/PMC22391/ https://ncbi.nlm.nih.gov/pubmed/10097134 https://ncbi.nlm.nih.gov/pmc/articles/PMC22392/ https://ncbi.nlm.nih.gov/pubmed/10097135 https://ncbi.nlm.nih.gov/pmc/articles/PMC22393/ https://ncbi.nlm.nih.gov/pubmed/10097136 https://ncbi.nlm.nih.gov/pmc/articles/PMC22394/ https://ncbi.nlm.nih.gov/pubmed/10097137 https://ncbi.nlm.nih.gov/pmc/articles/PMC22395/ https://ncbi.nlm.nih.gov/pubmed/10097138 https://ncbi.nlm.nih.gov/pmc/articles/PMC22396/ https://ncbi.nlm.nih.gov/pubmed/10097139 https://ncbi.nlm.nih.gov/pmc/articles/PMC22397/ https://ncbi.nlm.nih.gov/pubmed/10097140 https://ncbi.nlm.nih.gov/pmc/articles/PMC22398/ https://ncbi.nlm.nih.gov/pubmed/10097141 https://ncbi.nlm.nih.gov/pmc/articles/PMC22399/ https://ncbi.nlm.nih.gov/pubmed/10097142 https://ncbi.nlm.nih.gov/pmc/articles/PMC22400/ https://ncbi.nlm.nih.gov/pubmed/10097143 https://ncbi.nlm.nih.gov/pmc/articles/PMC22401/ https://ncbi.nlm.nih.gov/pubmed/10097144 https://ncbi.nlm.nih.gov/pmc/articles/PMC22402/ https://ncbi.nlm.nih.gov/pubmed/10097145 https://ncbi.nlm.nih.gov/pmc/articles/PMC22403/ https://ncbi.nlm.nih.gov/pubmed/10097146 https://ncbi.nlm.nih.gov/pmc/articles/PMC22404/ https://ncbi.nlm.nih.gov/pubmed/10097147 https://ncbi.nlm.nih.gov/pmc/articles/PMC22405/ https://ncbi.nlm.nih.gov/pubmed/10097148 https://ncbi.nlm.nih.gov/pmc/articles/PMC22406/ https://ncbi.nlm.nih.gov/pubmed/10097149 https://ncbi.nlm.nih.gov/pmc/articles/PMC22407/ https://ncbi.nlm.nih.gov/pubmed/10097150 https://ncbi.nlm.nih.gov/pmc/articles/PMC22408/ https://ncbi.nlm.nih.gov/pubmed/10097151 https://ncbi.nlm.nih.gov/pmc/articles/PMC22409/ https://ncbi.nlm.nih.gov/pubmed/10097152 https://ncbi.nlm.nih.gov/pmc/articles/PMC22410/ https://ncbi.nlm.nih.gov/pubmed/10097153 https://ncbi.nlm.nih.gov/pmc/articles/PMC22411/ https://ncbi.nlm.nih.gov/pubmed/10097154 https://ncbi.nlm.nih.gov/pmc/articles/PMC22412/ https://ncbi.nlm.nih.gov/pubmed/10097155 https://ncbi.nlm.nih.gov/pmc/articles/PMC22413/ https://ncbi.nlm.nih.gov/pubmed/10097156 https://ncbi.nlm.nih.gov/pmc/articles/PMC22414/ https://ncbi.nlm.nih.gov/pubmed/10097157 https://ncbi.nlm.nih.gov/pmc/articles/PMC22415/ https://ncbi.nlm.nih.gov/pubmed/10097158 https://ncbi.nlm.nih.gov/pmc/articles/PMC22416/ https://ncbi.nlm.nih.gov/pubmed/10097159 https://ncbi.nlm.nih.gov/pmc/articles/PMC22417/ https://ncbi.nlm.nih.gov/pubmed/10097160 https://ncbi.nlm.nih.gov/pmc/articles/PMC22418/ https://ncbi.nlm.nih.gov/pubmed/10097161 https://ncbi.nlm.nih.gov/pmc/articles/PMC22419/ https://ncbi.nlm.nih.gov/pubmed/10097162 https://ncbi.nlm.nih.gov/pmc/articles/PMC22420/ https://ncbi.nlm.nih.gov/pubmed/10097163 https://ncbi.nlm.nih.gov/pmc/articles/PMC22421/ https://ncbi.nlm.nih.gov/pubmed/10097164 https://ncbi.nlm.nih.gov/pmc/articles/PMC22422/ https://ncbi.nlm.nih.gov/pubmed/10097165 https://ncbi.nlm.nih.gov/pmc/articles/PMC22423/ https://ncbi.nlm.nih.gov/pubmed/10097166 https://ncbi.nlm.nih.gov/pmc/articles/PMC22424/ https://ncbi.nlm.nih.gov/pubmed/10097167 https://ncbi.nlm.nih.gov/pmc/articles/PMC22425/ https://ncbi.nlm.nih.gov/pubmed/10097168 https://ncbi.nlm.nih.gov/pmc/articles/PMC22426/ https://ncbi.nlm.nih.gov/pubmed/10097169 https://ncbi.nlm.nih.gov/pmc/articles/PMC22427/ https://ncbi.nlm.nih.gov/pubmed/10097170 https://ncbi.nlm.nih.gov/pmc/articles/PMC22428/ https://ncbi.nlm.nih.gov/pubmed/10097171 https://ncbi.nlm.nih.gov/pmc/articles/PMC22429/ https://ncbi.nlm.nih.gov/pubmed/10097172 https://ncbi.nlm.nih.gov/pmc/articles/PMC22430/ https://ncbi.nlm.nih.gov/pubmed/10097173 https://ncbi.nlm.nih.gov/pmc/articles/PMC22431/ https://ncbi.nlm.nih.gov/pubmed/10097174 https://ncbi.nlm.nih.gov/pmc/articles/PMC22432/ https://ncbi.nlm.nih.gov/pubmed/10097175 https://ncbi.nlm.nih.gov/pmc/articles/PMC22433/ https://ncbi.nlm.nih.gov/pubmed/10097176 https://ncbi.nlm.nih.gov/pmc/articles/PMC22434/ https://ncbi.nlm.nih.gov/pubmed/10097177
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Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

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