The Naphthyridinone GSK364735 Is a Novel, Potent Human Immunodeficiency Virus Type 1 Integrase Inhibitor and Antiretroviral

The naphthyridinone GSK364735 potently inhibited recombinant human immunodeficiency virus type 1 (HIV-1) integrase in a strand transfer assay (mean 50% inhibitory concentration ± standard deviation, 8 ± 2 nM). As expected based on the structure of the drug, it bound competitively with another two-me...

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Detalhes bibliográficos
Main Authors: Garvey, Edward P., Johns, Brian A., Gartland, Margaret J., Foster, Scott A., Miller, Wayne H., Ferris, Robert G., Hazen, Richard J., Underwood, Mark R., Boros, Eric E., Thompson, James B., Weatherhead, Jason G., Koble, Cecilia S., Allen, Scott H., Schaller, Lee T., Sherrill, Ronald G., Yoshinaga, Tomokazu, Kobayashi, Masanori, Wakasa-Morimoto, Chiaki, Miki, Shigeru, Nakahara, Koichiro, Noshi, Takeshi, Sato, Akihiko, Fujiwara, Tamio
Formato: Artigo
Idioma:English
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258521/
https://ncbi.nlm.nih.gov/pubmed/18160521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01218-07
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2258521/
https://ncbi.nlm.nih.gov/pubmed/18160521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01218-07

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