Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function

Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson’s disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (< 1year) DJ-1 (-/-) mice were hypoactive and had mild gait abnormaliti...

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Detalhes bibliográficos
Main Authors: Chandran, Jayanth S., Lin, Xian, Zapata, Agustin, Höke, Ahmet, Shimoji, Mika, Moore, Shonagh O’Leary, Galloway, Matthew P., Laird, Fiona M., Wong, Philip C., Price, Donald L., Bailey, Kathleen R., Crawley, Jacqueline N, Shippenberg, Toni, Cai, Huaibin
Formato: Artigo
Idioma:English
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2271119/
https://ncbi.nlm.nih.gov/pubmed/18187333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.11.011
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2271119/
https://ncbi.nlm.nih.gov/pubmed/18187333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.11.011

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