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Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function
Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson’s disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (< 1year) DJ-1 (-/-) mice were hypoactive and had mild gait abnormaliti...
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| Materialtyp: | Artikel |
| Språk: | English |
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2007
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271119/ https://ncbi.nlm.nih.gov/pubmed/18187333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.11.011 |
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pubmed-22711192009-03-01 Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function Chandran, Jayanth S. Lin, Xian Zapata, Agustin Höke, Ahmet Shimoji, Mika Moore, Shonagh O’Leary Galloway, Matthew P. Laird, Fiona M. Wong, Philip C. Price, Donald L. Bailey, Kathleen R. Crawley, Jacqueline N Shippenberg, Toni Cai, Huaibin Neurobiol Dis Article Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson’s disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (< 1year) DJ-1 (-/-) mice were hypoactive and had mild gait abnormalities. Older DJ-1(-/-), however, showed decreased bodyweight and grip strength, and more severe gait irregularities compared to wild-type littermates. The basal level of extracellular dopamine, evoked dopamine release and dopamine receptor D2 sensitivity appeared normal in the striatum of DJ-1(-/-) mice, which was consistent with similar results between DJ-1(-/-) and controls in behavioral paradigms specific for the dopaminergic system. An examination of spinal cord, nerve and muscle tissues failed to identify any pathological changes that were consistent with the noted motor deficits. Taken together, our findings suggest that loss of DJ-1 leads to progressive behavioral changes without significant alterations in nigrostriatal dopaminergic and spinal motor systems. 2007-12-04 2008-03 /pmc/articles/PMC2271119/ /pubmed/18187333 http://dx.doi.org/10.1016/j.nbd.2007.11.011 Text en |
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US National Library of Medicine |
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PubMed Central |
| language |
English |
| format |
Article |
| topic |
Article |
| spellingShingle |
Article Chandran, Jayanth S. Lin, Xian Zapata, Agustin Höke, Ahmet Shimoji, Mika Moore, Shonagh O’Leary Galloway, Matthew P. Laird, Fiona M. Wong, Philip C. Price, Donald L. Bailey, Kathleen R. Crawley, Jacqueline N Shippenberg, Toni Cai, Huaibin Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| description |
Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson’s disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (< 1year) DJ-1 (-/-) mice were hypoactive and had mild gait abnormalities. Older DJ-1(-/-), however, showed decreased bodyweight and grip strength, and more severe gait irregularities compared to wild-type littermates. The basal level of extracellular dopamine, evoked dopamine release and dopamine receptor D2 sensitivity appeared normal in the striatum of DJ-1(-/-) mice, which was consistent with similar results between DJ-1(-/-) and controls in behavioral paradigms specific for the dopaminergic system. An examination of spinal cord, nerve and muscle tissues failed to identify any pathological changes that were consistent with the noted motor deficits. Taken together, our findings suggest that loss of DJ-1 leads to progressive behavioral changes without significant alterations in nigrostriatal dopaminergic and spinal motor systems. |
| author |
Chandran, Jayanth S. Lin, Xian Zapata, Agustin Höke, Ahmet Shimoji, Mika Moore, Shonagh O’Leary Galloway, Matthew P. Laird, Fiona M. Wong, Philip C. Price, Donald L. Bailey, Kathleen R. Crawley, Jacqueline N Shippenberg, Toni Cai, Huaibin |
| author_facet |
Chandran, Jayanth S. Lin, Xian Zapata, Agustin Höke, Ahmet Shimoji, Mika Moore, Shonagh O’Leary Galloway, Matthew P. Laird, Fiona M. Wong, Philip C. Price, Donald L. Bailey, Kathleen R. Crawley, Jacqueline N Shippenberg, Toni Cai, Huaibin |
| author_sort |
Chandran, Jayanth S. |
| title |
Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| title_short |
Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| title_full |
Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| title_fullStr |
Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| title_full_unstemmed |
Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function |
| title_sort |
progressive behavioral deficits in dj-1 deficient mice are associated with normal nigrostriatal function |
| publishDate |
2007 |
| url |
https://ncbi.nlm.nih.gov/pmc/articles/PMC2271119/ https://ncbi.nlm.nih.gov/pubmed/18187333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.11.011 |
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1760531821159776256 |