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Progressive Behavioral Deficits in DJ-1 Deficient Mice are Associated with Normal Nigrostriatal Function
Loss-of-function mutations in the DJ-1 gene account for an autosomal recessive form of Parkinson’s disease (PD). To investigate the physiological functions of DJ-1 in vivo, we generated DJ-1 knockout (DJ-1(-/-)) mice. Younger (< 1year) DJ-1 (-/-) mice were hypoactive and had mild gait abnormaliti...
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| Main Authors: | , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | English |
| יצא לאור: |
2007
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2271119/ https://ncbi.nlm.nih.gov/pubmed/18187333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.11.011 |
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