Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in non-conventional RNA splicing

Ire1 is an ancient transmembrane sensor of ER-stress with dual protein kinase and ribonuclease activities. In response to ER stress, Ire1 catalyzes the splicing of target mRNAs in a spliceosome independent manner. We have determined the crystal structure of the dual-catalytic region of Ire1at 2.4Å r...

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Main Authors: Lee, Kenneth P. K., Dey, Madhusudan, Neculai, Dante, Cao, Chune, Dever, Thomas E., Sicheri, Frank
Formato: Artigo
Idioma:English
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276645/
https://ncbi.nlm.nih.gov/pubmed/18191223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.10.057
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2276645/
https://ncbi.nlm.nih.gov/pubmed/18191223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.10.057

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