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The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

BACKGROUND: Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that...

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Detalhes bibliográficos
Main Authors: Tharmanathan, Puvan, Calvert, Melanie, Hampton, John, Freemantle, Nick
Formato: Artigo
Idioma:English
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2279143/
https://ncbi.nlm.nih.gov/pubmed/18366697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2288-8-12
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