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Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a poorly defined mechanism, which involves virus binding to vitamin K-dependent blood coagulation factors. Here, we report t...

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Detalhes bibliográficos
Main Authors: Kalyuzhniy, O., Di Paolo, N. C., Silvestry, M., Hofherr, S. E., Barry, M. A., Stewart, P. L., Shayakhmetov, D. M.
Formato: Artigo
Idioma:English
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291105/
https://ncbi.nlm.nih.gov/pubmed/18391209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711757105
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