Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development

We have developed a nonheuristic genome topography scan (GTS) algorithm to characterize the patterns of genomic alterations in human glioblastoma (GBM), identifying frequent p18(INK4C) and p16(INK4A) codeletion. Functional reconstitution of p18(INK4C) in GBM cells null for both p16(INK4A) and p18(IN...

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Main Authors: Wiedemeyer, Ruprecht, Brennan, Cameron, Heffernan, Timothy P., Xiao, Yonghong, Mahoney, John, Protopopov, Alexei, Zheng, Hongwu, Bignell, Graham, Furnari, Frank, Cavenee, Webster K., Hahn, William C., Ichimura, Koichi, Collins, V. Peter, Chu, Gerald C., Stratton, Michael R., Ligon, Keith L., Futreal, P. Andrew, Chin, Lynda
Formato: Artigo
Idioma:English
Publicado em: Cell Press 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2292238/
https://ncbi.nlm.nih.gov/pubmed/18394558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.02.010
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2292238/
https://ncbi.nlm.nih.gov/pubmed/18394558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.02.010

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