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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

We and others recently generated mice with a targeted disruption of the insulin receptor substrate 1 (IRS-1) gene and demonstrated that they exhibited growth retardation and had resistance to the glucose-lowering effect of insulin. Insulin initiates its biological effects by activating at least two...

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Main Authors:	Yamauchi, T, Tobe, K, Tamemoto, H, Ueki, K, Kaburagi, Y, Yamamoto-Honda, R, Takahashi, Y, Yoshizawa, F, Aizawa, S, Akanuma, Y, Sonenberg, N, Yazaki, Y, Kadowaki, T, Carrozza, M J, DeLuca, N A, Runge, K W, Zakian, V A, An, W, Cho, S, Ishii, H, Wensink, P C, Ito, T, Bulger, M, Kobayashi, R, Kadonaga, J T, Faust, D M, Catherin, A M, Barbaux, S, Belkadi, L, Imaizumi-Scherrer, T, Weiss, M C, Roque, M C, Smith, P A, Blasquez, V C, Yin, M J, Gaynor, R B, Hildebrand, J D, Taylor, J M, Parsons, J T, Pomerance, M, Thang, M N, Tocque, B, Pierre, M, Drazinic, C M, Smerage, J B, López, M C, Baker, H V, Marcus, G A, Horiuchi, J, Silverman, N, Guarente, L, Roberts, S M, Winston, F, Bach, E A, Tanner, J W, Marsters, S, Ashkenazi, A, Aguet, M, Shaw, A S, Schreiber, R D, Lee, R H, Honigberg, S M, Longhese, M P, Fraschini, R, Plevani, P, Lucchini, G, Ngô, V, Gourdji, D, Laverrière, J N, Yashiroda, H, Oguchi, T, Yasuda, Y, Toh-E, A, Kikuchi, Y, Kovacech, B, Nasmyth, K, Schuster, T, Deitz, S B, Wu, C, Silve, S, Howell, K E, Melançon, P, Kahn, R A, Franzusoff, A, Löpez, C C, Nielsen, L, Edström, J E, Yankulov, K Y, Pandes, M, McCracken, S, Bouchard, D, Bentley, D L, Yang, L, Steussy, C N, Fuhrer, D K, Hamilton, J, Yang, Y C, Cairns, B R, Henry, N L, Kornberg, R D, Chiara, M D, Gozani, O, Bennett, M, Champion-Arnaud, P, Palandjian, L, Reed, R, Law, S F, Estojak, J, Wang, B, Mysliwiec, T, Kruh, G, Golemis, E A, Shore, P, Whitmarsh, A J, Bhaskaran, R, Davis, R J, Waltho, J P, Sharrocks, A D, Vu-Dac, N, Schoonjans, K, Kosykh, V, Dallongeville, J, Heyman, R A, Staels, B, Auwerx, J, Baskaran, R, Chiang, G G, Wang, J Y, Kang, J S, Krauss, R S, Kim, J, Shen, B, Rosen, C, Dorsett, D, Ebihara, K, Masuhiro, Y, Kitamoto, T, Suzawa, M, Uematsu, Y, Yoshizawa, T, Ono, T, Harada, H, Matsuda, K, Hasegawa, T, Masushige, S, Kato, S, Botz, J, Zerfass-Thome, K, Spitkovsky, D, Delius, H, Vogt, B, Eilers, M, Hatzigeorgiou, A, Jansen-Dürr, P, Sears, I B, MacGinnitie, M A, Kovacs, L G, Graves, R A, Yabana, N, Yamamoto, M, Stribinskis, V, Gao, G J, Sulo, P, Dang, Y L, Martin, N C, Melek, M, Greene, E C, Shippen, D E, Keil, R L, Wolfe, D, Reiner, T, Peterson, C J, Riley, J L, Eckner, R, Ludlow, J W, Lill, N L, Oldread, E, Arany, Z, Modjtahedi, N, DeCaprio, J A, Livingston, D M, Morgan, J A, Afar, D E, Park, H, Howell, B W, Rawlings, D J, Cooper, J, Witte, O N, Robertson, S C, Donoghue, D J, Knaus, P I, Lindemann, D, DeCoteau, J F, Perlman, R, Yankelev, H, Hille, M, Kadin, M E, Lodish, H F, Schumann, R R, Kirschning, C J, Unbehaun, A, Aberle, H P, Knope, H P, Lamping, N, Ulevitch, R J, Herrmann, F, Marechal-Drouard, L, Cosset, A, Remacle, C, Ramamonjisoa, D, Dietrich, A, Yeilding, N M, Rehman, M T, Lee, W M, McBratney, S, Sarnow, P, Lankenau, D H, Corces, V G, Engels, W R, Svaren, J, Sevetson, B R, Apel, E D, Zimonjic, D B, Popescu, N C, Milbrandt, J, Schwarz, E M, Van Antwerp, D, Verma, I M, Yohn, C B, Cohen, A, Danon, A, Mayfield, S P
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC231302/ https://ncbi.nlm.nih.gov/pubmed/8649419 https://ncbi.nlm.nih.gov/pmc/articles/PMC231303/ https://ncbi.nlm.nih.gov/pubmed/8649420 https://ncbi.nlm.nih.gov/pmc/articles/PMC231304/ https://ncbi.nlm.nih.gov/pubmed/8649421 https://ncbi.nlm.nih.gov/pmc/articles/PMC231305/ https://ncbi.nlm.nih.gov/pubmed/8649422 https://ncbi.nlm.nih.gov/pmc/articles/PMC231306/ https://ncbi.nlm.nih.gov/pubmed/8649423 https://ncbi.nlm.nih.gov/pmc/articles/PMC231307/ https://ncbi.nlm.nih.gov/pubmed/8649424 https://ncbi.nlm.nih.gov/pmc/articles/PMC231308/ https://ncbi.nlm.nih.gov/pubmed/8649425 https://ncbi.nlm.nih.gov/pmc/articles/PMC231309/ https://ncbi.nlm.nih.gov/pubmed/8649426 https://ncbi.nlm.nih.gov/pmc/articles/PMC231310/ https://ncbi.nlm.nih.gov/pubmed/8649427 https://ncbi.nlm.nih.gov/pmc/articles/PMC231311/ https://ncbi.nlm.nih.gov/pubmed/8649428 https://ncbi.nlm.nih.gov/pmc/articles/PMC231312/ https://ncbi.nlm.nih.gov/pubmed/8649429 https://ncbi.nlm.nih.gov/pmc/articles/PMC231313/ https://ncbi.nlm.nih.gov/pubmed/8649430 https://ncbi.nlm.nih.gov/pmc/articles/PMC231314/ https://ncbi.nlm.nih.gov/pubmed/8649431 https://ncbi.nlm.nih.gov/pmc/articles/PMC231315/ https://ncbi.nlm.nih.gov/pubmed/8649432 https://ncbi.nlm.nih.gov/pmc/articles/PMC231316/ https://ncbi.nlm.nih.gov/pubmed/8649433 https://ncbi.nlm.nih.gov/pmc/articles/PMC231317/ https://ncbi.nlm.nih.gov/pubmed/8668138 https://ncbi.nlm.nih.gov/pmc/articles/PMC231318/ https://ncbi.nlm.nih.gov/pubmed/8668139 https://ncbi.nlm.nih.gov/pmc/articles/PMC231319/ https://ncbi.nlm.nih.gov/pubmed/8668140 https://ncbi.nlm.nih.gov/pmc/articles/PMC231320/ https://ncbi.nlm.nih.gov/pubmed/8668141 https://ncbi.nlm.nih.gov/pmc/articles/PMC231321/ https://ncbi.nlm.nih.gov/pubmed/8668142 https://ncbi.nlm.nih.gov/pmc/articles/PMC231322/ https://ncbi.nlm.nih.gov/pubmed/8668143 https://ncbi.nlm.nih.gov/pmc/articles/PMC231323/ https://ncbi.nlm.nih.gov/pubmed/8668144 https://ncbi.nlm.nih.gov/pmc/articles/PMC231324/ https://ncbi.nlm.nih.gov/pubmed/8668145 https://ncbi.nlm.nih.gov/pmc/articles/PMC231325/ https://ncbi.nlm.nih.gov/pubmed/8668146 https://ncbi.nlm.nih.gov/pmc/articles/PMC231326/ https://ncbi.nlm.nih.gov/pubmed/8668147 https://ncbi.nlm.nih.gov/pmc/articles/PMC231327/ https://ncbi.nlm.nih.gov/pubmed/8668148 https://ncbi.nlm.nih.gov/pmc/articles/PMC231328/ https://ncbi.nlm.nih.gov/pubmed/8668149 https://ncbi.nlm.nih.gov/pmc/articles/PMC231329/ https://ncbi.nlm.nih.gov/pubmed/8668150 https://ncbi.nlm.nih.gov/pmc/articles/PMC231330/ https://ncbi.nlm.nih.gov/pubmed/8668151 https://ncbi.nlm.nih.gov/pmc/articles/PMC231331/ https://ncbi.nlm.nih.gov/pubmed/8668152 https://ncbi.nlm.nih.gov/pmc/articles/PMC231332/ https://ncbi.nlm.nih.gov/pubmed/8668153 https://ncbi.nlm.nih.gov/pmc/articles/PMC231333/ https://ncbi.nlm.nih.gov/pubmed/8668154 https://ncbi.nlm.nih.gov/pmc/articles/PMC231334/ https://ncbi.nlm.nih.gov/pubmed/8668155 https://ncbi.nlm.nih.gov/pmc/articles/PMC231335/ https://ncbi.nlm.nih.gov/pubmed/8668156 https://ncbi.nlm.nih.gov/pmc/articles/PMC231336/ https://ncbi.nlm.nih.gov/pubmed/8668157 https://ncbi.nlm.nih.gov/pmc/articles/PMC231337/ https://ncbi.nlm.nih.gov/pubmed/8668158 https://ncbi.nlm.nih.gov/pmc/articles/PMC231338/ https://ncbi.nlm.nih.gov/pubmed/8668159 https://ncbi.nlm.nih.gov/pmc/articles/PMC231339/ https://ncbi.nlm.nih.gov/pubmed/8668160 https://ncbi.nlm.nih.gov/pmc/articles/PMC231340/ https://ncbi.nlm.nih.gov/pubmed/8668161 https://ncbi.nlm.nih.gov/pmc/articles/PMC231341/ https://ncbi.nlm.nih.gov/pubmed/8668162 https://ncbi.nlm.nih.gov/pmc/articles/PMC231342/ https://ncbi.nlm.nih.gov/pubmed/8668163 https://ncbi.nlm.nih.gov/pmc/articles/PMC231343/ https://ncbi.nlm.nih.gov/pubmed/8668164 https://ncbi.nlm.nih.gov/pmc/articles/PMC231344/ https://ncbi.nlm.nih.gov/pubmed/8668165 https://ncbi.nlm.nih.gov/pmc/articles/PMC231345/ https://ncbi.nlm.nih.gov/pubmed/8668166 https://ncbi.nlm.nih.gov/pmc/articles/PMC231346/ https://ncbi.nlm.nih.gov/pubmed/8668167 https://ncbi.nlm.nih.gov/pmc/articles/PMC231347/ https://ncbi.nlm.nih.gov/pubmed/8668168 https://ncbi.nlm.nih.gov/pmc/articles/PMC231348/ https://ncbi.nlm.nih.gov/pubmed/8668169 https://ncbi.nlm.nih.gov/pmc/articles/PMC231349/ https://ncbi.nlm.nih.gov/pubmed/8668170 https://ncbi.nlm.nih.gov/pmc/articles/PMC231350/ https://ncbi.nlm.nih.gov/pubmed/8668171 https://ncbi.nlm.nih.gov/pmc/articles/PMC231351/ https://ncbi.nlm.nih.gov/pubmed/8668172
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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

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