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Functional analysis of CNK in RAS signaling

Connector enhancer of KSR (CNK) is a multidomain protein required for RAS signaling. Its C-terminal portion (CNK(C-term)) directly binds to RAF. Herein, we show that the N-terminal portion of CNK (CNK(N-term)) strongly cooperates with RAS, whereas CNK(C-term) efficiently blocks RAS- and RAF-dependen...

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Detalhes bibliográficos
Main Authors:	Therrien, Marc, Wong, Allan M., Kwan, Elaine, Rubin, Gerald M., Khan, Javed, Bittner, Michael L., Saal, Lao H., Teichmann, Ulrike, Azorsa, David O., Gooden, Gerald C., Pavan, William J., Trent, Jeffrey M., Meltzer, Paul S., Mata de Urquiza, Alexander, Solomin, Ludmila, Perlmann, Thomas, Chatterjee, Pradeep K., Yarnall, David P., Haneline, Stephen A., Godlevski, Michele M., Thornber, Simon J., Robinson, Phil S., Davies, Heather E., White, Nicola J., Riley, John H., Shepherd, Nancy S., Shiina, Takashi, Tamiya, Gen, Oka, Akira, Takishima, Nobusada, Yamagata, Tetsushi, Kikkawa, Eri, Iwata, Kyoko, Tomizawa, Maiko, Okuaki, Noriko, Kuwano, Yuko, Watanabe, Koji, Fukuzumi, Yasuhito, Itakura, Shoko, Sugawara, Chiyo, Ono, Ayako, Yamazaki, Masaaki, Tashiro, Hiroyuki, Ando, Asako, Ikemura, Toshimichi, Soeda, Eiichi, Kimura, Minoru, Bahram, Seiamak, Inoko, Hidetoshi, Kim, Jaehyoung, Nietfeldt, Joseph, Benson, Andrew K., Duitman, Erwin H., Hamoen, Leendert W., Rembold, Martina, Venema, Gerard, Seitz, Harald, Saenger, Wolfram, Bernhard, Frank, Reinhardt, Richard, Schmidt, Manuel, Ullrich, Christian, Stein, Torsten, Leenders, Frank, Vater, Joachim, Klungland, Arne, Rosewell, Ian, Hollenbach, Stephan, Larsen, Elisabeth, Daly, Graham, Epe, Bernd, Seeberg, Erling, Lindahl, Tomas, Barnes, Deborah E., Kieper, William C., Jameson, Stephen C., Gilfillan, Susan, Kühn, Lukas C., Moret, Rémy, Schulze, Johannes B., Lebeau, Annette, Schümann, Klaus, Rigler, R., Pramanik, A., Jonasson, P., Kratz, G., Jansson, O. T., Nygren, P.-Å., Ståhl, S., Ekberg, K., Johansson, B.-L., Uhlén, S., Uhlén, M., Jörnvall, H., Wahren, J., Lipshutz, G. S., Sarkar, R., Flebbe-Rehwaldt, L., Kazazian, H., Gaensler, K. M. L., Dibbert, Birgit, Weber, Martina, Nikolaizik, Wilfried H., Vogt, Peter, Schöni, Martin H., Blaser, Kurt, Simon, Hans-Uwe, Ramakrishnan, Vanitha, Reeves, Peter S., DeGuzman, Francis, Deshpande, Usha, Ministri-Madrid, Kathleen, DuBridge, Robert B., Phillips, David R., Ungewickell, Alexander J., Majerus, Philip W., Nozaki, Tadashige, Masutani, Mitsuko, Watanabe, Masatoshi, Ochiya, Takahiro, Hasegawa, Fumio, Nakagama, Hitoshi, Suzuki, Hiroshi, Sugimura, Takashi, Oshikawa, Katsuhisa, Shi, Fushun, Rakhmilevich, Alexander L., Sondel, Paul M., Mahvi, David M., Yang, Ning-Sun, Wallerath, Thomas, Witte, Klaus, Schäfer, Stephan C., Schwarz, Petra M., Prellwitz, Winfried, Wohlfart, Paulus, Kleinert, Hartmut, Lehr, Hans-Anton, Lemmer, Björn, Förstermann, Ulrich, Hamza, Iqbal, Schaefer, Mark, Klomp, Leo W. J., Gitlin, Jonathan D., Li, Chiang J., Li, You-Zhi, Pinto, Antonio Ventura, Pardee, Arthur B., Munger, Karen A., Montero, Angel, Fukunaga, Megumu, Uda, Susumu, Yura, Takafumi, Imai, Enyu, Kaneda, Yasufumi, Valdivielso, José M., Badr, Kamal F., Li, Hongwei, Lawson, John A., Reilly, Muredach, Adiyaman, Mustafa, Hwang, Seong-Woo, Rokach, Joshua, FitzGerald, Garret A., Zuther, E., Johnson, J. J., Haselkorn, R., McLeod, R., Gornicki, P., Norris, Tracy L., Bäumler, Andreas J., Johnson, Barbara W., Olson, Ken E., Allen-Miura, Tanya, Rayms-Keller, Alfredo, Carlson, Jonathan O., Coates, Craig J., Jasinskiene, Nijole, James, Anthony A., Beaty, Barry J., Higgs, Stephen, Yang, Jin, Bogerd, Hal P., Peng, Sheila, Wiegand, Heather, Truant, Ray, Cullen, Bryan R., Wolosker, Herman, Blackshaw, Seth, Snyder, Solomon H., Reaux, Annabelle, Fournie-Zaluski, Marie Claude, David, Christelle, Zini, Sylvie, Roques, Bernard P., Corvol, Pierre, Llorens-Cortes, Catherine, Palma, Eleonora, Fucile, Sergio, Barabino, Benedetta, Miledi, Ricardo, Eusebi, Fabrizio, van Praag, Henriette, Christie, Brian R., Sejnowski, Terrence J., Gage, Fred H., Honey, Garry D., Bullmore, Edward T., Soni, William, Varatheesan, Malini, Williams, Steve C. R., Sharma, Tonmoy, Dunaevsky, Anna, Tashiro, Ayumu, Majewska, Ania, Mason, Carol, Yuste, Rafael, Grunwald, Maria E., Zhong, Haining, Lai, Jun, Yau, King-Wai, Galvin, James E., Uryu, Kunihiro, Lee, Virginia M.-Y., Trojanowski, John Q., Karten, Y. J. G., Nair, S. M., van Essen, L., Sibug, R., Joëls, M., Zindy, Frederique, Cunningham, Justine J., Sherr, Charles J., Jogal, Sachin, Smeyne, Richard J., Roussel, Martine F., Chen, Dong, Buchanan, Gordon F., Ding, Jian M., Hannibal, Jens, Gillette, Martha U., Li, Chenjian, Geng, Chaoxian, Leung, Hung-Tat, Hong, Young Seok, Strong, Lydia L. R., Schneuwly, Stephan, Pak, William L., Golomb, David, Ermentrout, G. Bard, Benowitz, Larry I., Goldberg, David E., Madsen, Joseph R., Soni, Deepa, Irwin, Nina, Lein, E. S., Finney, E. M., McQuillen, P. S., Shatz, C. J., Yrjänheikki, Juha, Tikka, Tiina, Keinänen, Riitta, Goldsteins, Gundars, Chan, Pak H., Koistinaho, Jari, Behar, Oded, Mizuno, Keiko, Badminton, Mike, Woolf, Clifford J., Broberger, Christian, Holmberg, Kristina, Kuhar, Michael J., Hökfelt, Tomas, Griffin, Lisa D., Mellon, Synthia H., Marsh, Donald J., Baraban, Scott C., Hollopeter, Gunther, Palmiter, Richard D., Lane, Michelle A., Chen, Anne C., Roman, Shaun D., Derguini, Fadila, Gudas, Lorraine J., Danker, T., Schillers, H., Storck, J., Shahin, V., Krämer, B., Wilhelmi, M., Oberleithner, H., Tian, Rong, Miao, Wenfeng, Spindler, Matthias, Javadpour, Maryam M., McKinney, Ronald, Bowman, Joel C., Buttrick, Peter M., Ingwall, Joanne S., Lev, Sophie, Sharon, Amir, Hadar, Ruthi, Ma, Hong, Horwitz, Benjamin A.
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	The National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC23935/ https://ncbi.nlm.nih.gov/pubmed/10557308 https://ncbi.nlm.nih.gov/pmc/articles/PMC23936/ https://ncbi.nlm.nih.gov/pubmed/10557309 https://ncbi.nlm.nih.gov/pmc/articles/PMC23937/ https://ncbi.nlm.nih.gov/pubmed/10557310 https://ncbi.nlm.nih.gov/pmc/articles/PMC23938/ https://ncbi.nlm.nih.gov/pubmed/10557311 https://ncbi.nlm.nih.gov/pmc/articles/PMC23939/ https://ncbi.nlm.nih.gov/pubmed/10557312 https://ncbi.nlm.nih.gov/pmc/articles/PMC23940/ https://ncbi.nlm.nih.gov/pubmed/10557313 https://ncbi.nlm.nih.gov/pmc/articles/PMC23941/ https://ncbi.nlm.nih.gov/pubmed/10557314 https://ncbi.nlm.nih.gov/pmc/articles/PMC23942/ https://ncbi.nlm.nih.gov/pubmed/10557315 https://ncbi.nlm.nih.gov/pmc/articles/PMC23943/ https://ncbi.nlm.nih.gov/pubmed/10557316 https://ncbi.nlm.nih.gov/pmc/articles/PMC23944/ https://ncbi.nlm.nih.gov/pubmed/10557317 https://ncbi.nlm.nih.gov/pmc/articles/PMC23945/ https://ncbi.nlm.nih.gov/pubmed/10557318 https://ncbi.nlm.nih.gov/pmc/articles/PMC23946/ https://ncbi.nlm.nih.gov/pubmed/10557319 https://ncbi.nlm.nih.gov/pmc/articles/PMC23947/ https://ncbi.nlm.nih.gov/pubmed/10557320 https://ncbi.nlm.nih.gov/pmc/articles/PMC23948/ https://ncbi.nlm.nih.gov/pubmed/10557321 https://ncbi.nlm.nih.gov/pmc/articles/PMC23949/ https://ncbi.nlm.nih.gov/pubmed/10557322 https://ncbi.nlm.nih.gov/pmc/articles/PMC23950/ https://ncbi.nlm.nih.gov/pubmed/10557323 https://ncbi.nlm.nih.gov/pmc/articles/PMC23951/ https://ncbi.nlm.nih.gov/pubmed/10557324 https://ncbi.nlm.nih.gov/pmc/articles/PMC23952/ https://ncbi.nlm.nih.gov/pubmed/10557325 https://ncbi.nlm.nih.gov/pmc/articles/PMC23953/ https://ncbi.nlm.nih.gov/pubmed/10557326 https://ncbi.nlm.nih.gov/pmc/articles/PMC23954/ https://ncbi.nlm.nih.gov/pubmed/10557327 https://ncbi.nlm.nih.gov/pmc/articles/PMC23955/ https://ncbi.nlm.nih.gov/pubmed/10557328 https://ncbi.nlm.nih.gov/pmc/articles/PMC23956/ https://ncbi.nlm.nih.gov/pubmed/10557329 https://ncbi.nlm.nih.gov/pmc/articles/PMC23957/ https://ncbi.nlm.nih.gov/pubmed/10557330 https://ncbi.nlm.nih.gov/pmc/articles/PMC23958/ https://ncbi.nlm.nih.gov/pubmed/10557331 https://ncbi.nlm.nih.gov/pmc/articles/PMC23959/ https://ncbi.nlm.nih.gov/pubmed/10557332 https://ncbi.nlm.nih.gov/pmc/articles/PMC23960/ https://ncbi.nlm.nih.gov/pubmed/10557333 https://ncbi.nlm.nih.gov/pmc/articles/PMC23961/ https://ncbi.nlm.nih.gov/pubmed/10557334 https://ncbi.nlm.nih.gov/pmc/articles/PMC23962/ https://ncbi.nlm.nih.gov/pubmed/10557335 https://ncbi.nlm.nih.gov/pmc/articles/PMC23963/ https://ncbi.nlm.nih.gov/pubmed/10557336 https://ncbi.nlm.nih.gov/pmc/articles/PMC23964/ https://ncbi.nlm.nih.gov/pubmed/10557337 https://ncbi.nlm.nih.gov/pmc/articles/PMC23965/ https://ncbi.nlm.nih.gov/pubmed/10557338 https://ncbi.nlm.nih.gov/pmc/articles/PMC23966/ https://ncbi.nlm.nih.gov/pubmed/10557339 https://ncbi.nlm.nih.gov/pmc/articles/PMC23967/ https://ncbi.nlm.nih.gov/pubmed/10557340 https://ncbi.nlm.nih.gov/pmc/articles/PMC23968/ https://ncbi.nlm.nih.gov/pubmed/10557341 https://ncbi.nlm.nih.gov/pmc/articles/PMC23969/ https://ncbi.nlm.nih.gov/pubmed/10557342 https://ncbi.nlm.nih.gov/pmc/articles/PMC23970/ https://ncbi.nlm.nih.gov/pubmed/10557343 https://ncbi.nlm.nih.gov/pmc/articles/PMC23971/ https://ncbi.nlm.nih.gov/pubmed/10557344 https://ncbi.nlm.nih.gov/pmc/articles/PMC23972/ https://ncbi.nlm.nih.gov/pubmed/10557345 https://ncbi.nlm.nih.gov/pmc/articles/PMC23973/ https://ncbi.nlm.nih.gov/pubmed/10557346 https://ncbi.nlm.nih.gov/pmc/articles/PMC23974/ https://ncbi.nlm.nih.gov/pubmed/10557347 https://ncbi.nlm.nih.gov/pmc/articles/PMC23975/ https://ncbi.nlm.nih.gov/pubmed/10557348 https://ncbi.nlm.nih.gov/pmc/articles/PMC23976/ https://ncbi.nlm.nih.gov/pubmed/10557349 https://ncbi.nlm.nih.gov/pmc/articles/PMC23977/ https://ncbi.nlm.nih.gov/pubmed/10557350 https://ncbi.nlm.nih.gov/pmc/articles/PMC23978/ https://ncbi.nlm.nih.gov/pubmed/10557351 https://ncbi.nlm.nih.gov/pmc/articles/PMC23979/ https://ncbi.nlm.nih.gov/pubmed/10557352 https://ncbi.nlm.nih.gov/pmc/articles/PMC23980/ https://ncbi.nlm.nih.gov/pubmed/10557353 https://ncbi.nlm.nih.gov/pmc/articles/PMC23981/ https://ncbi.nlm.nih.gov/pubmed/10557354 https://ncbi.nlm.nih.gov/pmc/articles/PMC23982/ https://ncbi.nlm.nih.gov/pubmed/10557355 https://ncbi.nlm.nih.gov/pmc/articles/PMC23983/ https://ncbi.nlm.nih.gov/pubmed/10557356 https://ncbi.nlm.nih.gov/pmc/articles/PMC23984/ https://ncbi.nlm.nih.gov/pubmed/10557357
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Functional analysis of CNK in RAS signaling

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