A novel polymorphism of the human CD40 receptor with enhanced function

CD40 signaling is critical for innate and adaptive immunity against pathogens, and the cytoplasmic domain of CD40 is highly conserved both within and between species. A novel missense single nucleotide polymorphism (SNP) in the cytoplasmic domain of CD40 at position 227 (P227A) was identified, which...

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Autors principals: Peters, Anna L., Plenge, Robert M., Graham, Robert R., Altshuler, David M., Moser, Kathy L., Gaffney, Patrick M., Bishop, Gail A.
Format: Article
Idioma:English
Publicat: American Society of Hematology 2008
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518891/
https://ncbi.nlm.nih.gov/pubmed/18591382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-138925
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2518891/
https://ncbi.nlm.nih.gov/pubmed/18591382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-138925

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