N-phosphonacetyl-L-isoasparagine a Potent and Specific Inhibitor of E. coli Aspartate Transcarbamoylase

The synthesis of a new inhibitor, N-phosphonacetyl-L-isoasparagine (PALI), of Escherichia coli aspartate transcarbamoylase (ATCase) is reported, as well as structural studies of the enzyme·PALI complex. PALI was synthesized in 7 steps from β-benzyl L-aspartate. The K(D) of PALI was 2 μM. Kinetics an...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Eldo, Joby, Cardia, James P., O’Day, Elizabeth M., Xia, Jiarong, Tsurata, Hiro, Kantrowitz, Evan R.
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: 2006
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538380/
https://ncbi.nlm.nih.gov/pubmed/17004708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0607294
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC2538380/
https://ncbi.nlm.nih.gov/pubmed/17004708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0607294

Benzer Materyaller