Dominant Alleles Identify SET Domain Residues Required for Histone Methyltransferase of Polycomb Repressive Complex 2

Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutan...

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Detalhes bibliográficos
Main Authors: Joshi, Preeti, Carrington, Elizabeth A., Wang, Liangjun, Ketel, Carrie S., Miller, Ellen L., Jones, Richard S., Simon, Jeffrey A.
Formato: Artigo
Idioma:English
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Transcription, Chromatin, and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562053/
https://ncbi.nlm.nih.gov/pubmed/18693240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804442200
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2562053/
https://ncbi.nlm.nih.gov/pubmed/18693240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804442200

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