One-hit effects in cancer: Altered proteome of morphologically normal colon crypts in Familial Adenomatous Polyposis

We studied patients with Familial Adenomatous Polyposis (FAP), because they are virtually certain to develop colon cancer, and because much is known about the causative APC gene. We hypothesized that the inherited heterozygous mutation itself leads to changes in the proteome of morphologically norma...

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Detalhes bibliográficos
Main Authors: Yeung, Anthony T., Patel, Bhavinkumar B., Li, Xin-Ming, Seeholzer, Steven H., Coudry, Renata A., Cooper, Harry S., Bellacosa, Alfonso, Boman, Bruce M., Zhang, Tao, Litwin, Samuel, Ross, Eric A., Conrad, Peggy, Crowell, James A., Kopelovich, Levy, Knudson, Alfred
Formato: Artigo
Idioma:English
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562578/
https://ncbi.nlm.nih.gov/pubmed/18794146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0856
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Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC2562578/
https://ncbi.nlm.nih.gov/pubmed/18794146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0856

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