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Trafficking of Membrane-Associated Proteins to Cone Photoreceptor Outer Segments Requires the Chromophore 11-cis-Retinal
Lecithin retinol acyl transferase (LRAT) and retinal pigment epithelium protein 65 (RPE65) are key enzymes of the retinoid cycle. In Lrat(−/−) and Rpe65(−/−) mice, models of human Leber congenital amaurosis, the retinoid cycle is disrupted and 11-cis-retinal, the chromophore of visual pigments, is n...
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| Asıl Yazarlar: | , , , , , , , , |
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| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Society for Neuroscience
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562706/ https://ncbi.nlm.nih.gov/pubmed/18400900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0317-08.2008 |
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