Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain

BACKGROUND AND PURPOSE: Accurate prediction of biophase pharmacokinetics (PK) is essential to optimize pharmacotherapy in epilepsy. Here, we characterized the PK of the active metabolite of oxcarbazepine, 10,11-dihydro-10-hydroxy-carbamazepine (MHD) in plasma and in the hippocampus. Simultaneously,...

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Main Authors: Clinckers, R, Smolders, I, Michotte, Y, Ebinger, G, Danhof, M, Voskuyl, R A, Pasqua, O Della
Formato: Artigo
Idioma:English
Publicado em: Nature Publishing Group 2008
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Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597256/
https://ncbi.nlm.nih.gov/pubmed/18836479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.366
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2597256/
https://ncbi.nlm.nih.gov/pubmed/18836479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.366

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