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Analgesic effects of N-acetylmuramyl-L-alanyl-D-isoglutamine in decreasing the acetic acid-induced abdominal-writhing response.

A new pharmacological action of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) is described. Pretreatment of male ddY mice with MDP, but not its biologically inactive analogs, significantly decreased the frequency of acetic acid-induced writhing movements more effectively than did acetylsalicylic aci...

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Detalhes bibliográficos
Main Authors:	Ogawa, T, Kotani, S, Marchitto, K S, Smith, S G, Locht, C, Keith, J M, Jones, K F, Fischetti, V A, Repo, H, Leirisalo-Repo, M, Nurminen, M, Mäkelä, P H, Gulig, P A, Patrick, C C, Hermanstorfer, L, McCracken, G H, Hansen, E J, Clerc, P L, Ryter, A, Mounier, J, Sansonetti, P J, Klimpel, K R, Goldman, W E, Goetz, M B, Silverblatt, F J, Nugent, K M, Fick, R B, Iwata, M, Shimozato, T, Tokiwa, H, Tsubura, E, Runnels, P L, Moseley, S L, Moon, H W, Miller, K M, Dearborn, D G, Sorensen, R U, Hussein, S, Curtis, J, Akuffo, H, Turk, J L, Ganz, T, Sikkema, D J, Brubaker, R R, Woods, D E, Que, J U, Buchmüller-Rouiller, Y, Mauël, J, Lawlor, K M, Daskaleros, P A, Robinson, R E, Payne, S M, Ramphal, R, Guay, C, Pier, G B, Charoenvit, Y, Leef, M F, Yuan, L F, Sedegah, M, Beaudoin, R L, Gamazo, C, Moriyón, I, Sundstrom, P M, Nichols, E J, Kenny, G E, Mikx, F H, de Jong, M H, Kothary, M H, Richardson, S H, Frandsen, E V, Reinholdt, J, Kilian, M, Blackwood, L L, Lin, T, Rowe, J I, Dhaliwal, J S, Liew, F Y, Takahashi, N, Abbe, K, Takahashi-Abbe, S, Yamada, T, Cole, G T, Kirkland, T N, Sun, S H, Chong, K T, Allen, J B, Wilder, R L, Sibley, L D, Franzblau, S G, Krahenbuhl, J L, Hammond, B F, Lillard, S E, Stevens, R H, Hojo, S, Mitsutomi, M, Sakai, D K, Nishimori, K, Yugi, H, Naiki, M, Sugimura, T, Tanaka, Y, Nonomura, I, Yokomizo, Y, Kubo, S, Fujimura, S, Nakamura, T, Hill, J L, Yu, D T, Mazer, M A, Kovacs, J A, Swan, J C, Parrillo, J E, Masur, H, Simecka, J W, Cassell, G H, Pesanti, E L, Dromer, F, Salamero, J, Contrepois, A, Carbon, C, Yeni, P, Charreire, J, Bisno, A L, Craven, D E, McCabe, W R, Kapp, A, Freudenberg, M, Galanos, C, Sugden, E A, Samagh, B S, Bundle, D R, Duncan, J R, Bird, P S, Seymour, G J, Ware, P L, Kasper, L H, Hughes, H P, Speer, C A, Kyle, J E, Dubey, J P
Formato:	Artigo
Idioma:	English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English English
Publicado em:	1987
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC260358/ https://ncbi.nlm.nih.gov/pubmed/3804449 https://ncbi.nlm.nih.gov/pmc/articles/PMC260363/ https://ncbi.nlm.nih.gov/pubmed/3818081 https://ncbi.nlm.nih.gov/pmc/articles/PMC260364/ https://ncbi.nlm.nih.gov/pubmed/3546129 https://ncbi.nlm.nih.gov/pmc/articles/PMC260365/ https://ncbi.nlm.nih.gov/pubmed/3818082 https://ncbi.nlm.nih.gov/pmc/articles/PMC260366/ https://ncbi.nlm.nih.gov/pubmed/2434425 https://ncbi.nlm.nih.gov/pmc/articles/PMC260367/ https://ncbi.nlm.nih.gov/pubmed/3546130 https://ncbi.nlm.nih.gov/pmc/articles/PMC260368/ https://ncbi.nlm.nih.gov/pubmed/3818083 https://ncbi.nlm.nih.gov/pmc/articles/PMC260369/ https://ncbi.nlm.nih.gov/pubmed/2880806 https://ncbi.nlm.nih.gov/pmc/articles/PMC260370/ https://ncbi.nlm.nih.gov/pubmed/3818084 https://ncbi.nlm.nih.gov/pmc/articles/PMC260371/ https://ncbi.nlm.nih.gov/pubmed/3493219 https://ncbi.nlm.nih.gov/pmc/articles/PMC260372/ https://ncbi.nlm.nih.gov/pubmed/2880807 https://ncbi.nlm.nih.gov/pmc/articles/PMC260373/ https://ncbi.nlm.nih.gov/pubmed/3028961 https://ncbi.nlm.nih.gov/pmc/articles/PMC260374/ https://ncbi.nlm.nih.gov/pubmed/2950059 https://ncbi.nlm.nih.gov/pmc/articles/PMC260375/ https://ncbi.nlm.nih.gov/pubmed/3643886 https://ncbi.nlm.nih.gov/pmc/articles/PMC260376/ https://ncbi.nlm.nih.gov/pubmed/3818085 https://ncbi.nlm.nih.gov/pmc/articles/PMC260377/ https://ncbi.nlm.nih.gov/pubmed/3102377 https://ncbi.nlm.nih.gov/pmc/articles/PMC260378/ https://ncbi.nlm.nih.gov/pubmed/3546131 https://ncbi.nlm.nih.gov/pmc/articles/PMC260379/ https://ncbi.nlm.nih.gov/pubmed/3028962 https://ncbi.nlm.nih.gov/pmc/articles/PMC260380/ https://ncbi.nlm.nih.gov/pubmed/2880808 https://ncbi.nlm.nih.gov/pmc/articles/PMC260381/ https://ncbi.nlm.nih.gov/pubmed/2434426 https://ncbi.nlm.nih.gov/pmc/articles/PMC260382/ https://ncbi.nlm.nih.gov/pubmed/3818086 https://ncbi.nlm.nih.gov/pmc/articles/PMC260383/ https://ncbi.nlm.nih.gov/pubmed/3546132 https://ncbi.nlm.nih.gov/pmc/articles/PMC260384/ https://ncbi.nlm.nih.gov/pubmed/2434427 https://ncbi.nlm.nih.gov/pmc/articles/PMC260385/ https://ncbi.nlm.nih.gov/pubmed/3818087 https://ncbi.nlm.nih.gov/pmc/articles/PMC260386/ https://ncbi.nlm.nih.gov/pubmed/3546133 https://ncbi.nlm.nih.gov/pmc/articles/PMC260387/ https://ncbi.nlm.nih.gov/pubmed/3102378 https://ncbi.nlm.nih.gov/pmc/articles/PMC260388/ https://ncbi.nlm.nih.gov/pubmed/3818088 https://ncbi.nlm.nih.gov/pmc/articles/PMC260389/ https://ncbi.nlm.nih.gov/pubmed/3818089 https://ncbi.nlm.nih.gov/pmc/articles/PMC260390/ https://ncbi.nlm.nih.gov/pubmed/3102379 https://ncbi.nlm.nih.gov/pmc/articles/PMC260391/ https://ncbi.nlm.nih.gov/pubmed/3546134 https://ncbi.nlm.nih.gov/pmc/articles/PMC260392/ https://ncbi.nlm.nih.gov/pubmed/3546135 https://ncbi.nlm.nih.gov/pmc/articles/PMC260393/ https://ncbi.nlm.nih.gov/pubmed/3546136 https://ncbi.nlm.nih.gov/pmc/articles/PMC260394/ https://ncbi.nlm.nih.gov/pubmed/3818090 https://ncbi.nlm.nih.gov/pmc/articles/PMC260395/ https://ncbi.nlm.nih.gov/pubmed/3818091 https://ncbi.nlm.nih.gov/pmc/articles/PMC260396/ https://ncbi.nlm.nih.gov/pubmed/3818092 https://ncbi.nlm.nih.gov/pmc/articles/PMC260397/ https://ncbi.nlm.nih.gov/pubmed/3818093 https://ncbi.nlm.nih.gov/pmc/articles/PMC260398/ https://ncbi.nlm.nih.gov/pubmed/3818094 https://ncbi.nlm.nih.gov/pmc/articles/PMC260399/ https://ncbi.nlm.nih.gov/pubmed/3546137 https://ncbi.nlm.nih.gov/pmc/articles/PMC260400/ https://ncbi.nlm.nih.gov/pubmed/3493220 https://ncbi.nlm.nih.gov/pmc/articles/PMC260401/ https://ncbi.nlm.nih.gov/pubmed/3546138 https://ncbi.nlm.nih.gov/pmc/articles/PMC260402/ https://ncbi.nlm.nih.gov/pubmed/3493221 https://ncbi.nlm.nih.gov/pmc/articles/PMC260403/ https://ncbi.nlm.nih.gov/pubmed/3493222 https://ncbi.nlm.nih.gov/pmc/articles/PMC260404/ https://ncbi.nlm.nih.gov/pubmed/3546139 https://ncbi.nlm.nih.gov/pmc/articles/PMC260405/ https://ncbi.nlm.nih.gov/pubmed/3546140 https://ncbi.nlm.nih.gov/pmc/articles/PMC260406/ https://ncbi.nlm.nih.gov/pubmed/3102380 https://ncbi.nlm.nih.gov/pmc/articles/PMC260407/ https://ncbi.nlm.nih.gov/pubmed/3818095 https://ncbi.nlm.nih.gov/pmc/articles/PMC260408/ https://ncbi.nlm.nih.gov/pubmed/3818096 https://ncbi.nlm.nih.gov/pmc/articles/PMC260409/ https://ncbi.nlm.nih.gov/pubmed/3818097 https://ncbi.nlm.nih.gov/pmc/articles/PMC260410/ https://ncbi.nlm.nih.gov/pubmed/3818098 https://ncbi.nlm.nih.gov/pmc/articles/PMC260411/ https://ncbi.nlm.nih.gov/pubmed/3102381
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Analgesic effects of N-acetylmuramyl-L-alanyl-D-isoglutamine in decreasing the acetic acid-induced abdominal-writhing response.

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