Expression of an activating mutation in the gene encoding the K(ATP) channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Neonatal diabetes is a rare monogenic form of diabetes that usually presents within the first six months of life. It is commonly caused by gain-of-function mutations in the genes encoding the Kir6.2 and SUR1 subunits of the plasmalemmal ATP-sensitive K(+) (K(ATP)) channel. To better understand this...

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Main Authors: Girard, Christophe A., Wunderlich, F. Thomas, Shimomura, Kenju, Collins, Stephan, Kaizik, Stephan, Proks, Peter, Abdulkader, Fernando, Clark, Anne, Ball, Vicky, Zubcevic, Lejla, Bentley, Liz, Clark, Rebecca, Church, Chris, Hugill, Alison, Galvanovskis, Juris, Cox, Roger, Rorsman, Patrik, Brüning, Jens C., Ashcroft, Frances M.
Formato: Artigo
Idioma:English
Publicado em: American Society for Clinical Investigation 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613450/
https://ncbi.nlm.nih.gov/pubmed/19065048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35772
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2613450/
https://ncbi.nlm.nih.gov/pubmed/19065048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35772

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