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A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL
The chaperonin GroEL is a megadalton-sized molecular machine that plays an essential role in the bacterial cell assisting protein folding to the native state through actions requiring ATP binding and hydrolysis. A combination of medicinal chemistry and genetics has been employed to generate an ortho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633924/ https://ncbi.nlm.nih.gov/pubmed/19110421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.12.015 |
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