Proteasomal Turnover of Hepatitis C Virus Core Protein Is Regulated by Two Distinct Mechanisms: a Ubiquitin-Dependent Mechanism and a Ubiquitin-Independent but PA28γ-Dependent Mechanism

We have previously reported on the ubiquitylation and degradation of hepatitis C virus core protein. Here we demonstrate that proteasomal degradation of the core protein is mediated by two distinct mechanisms. One leads to polyubiquitylation, in which lysine residues in the N-terminal region are pre...

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Autors principals: Suzuki, Ryosuke, Moriishi, Kohji, Fukuda, Kouichirou, Shirakura, Masayuki, Ishii, Koji, Shoji, Ikuo, Wakita, Takaji, Miyamura, Tatsuo, Matsuura, Yoshiharu, Suzuki, Tetsuro
Format: Article
Idioma:English
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Virus-Cell Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643730/
https://ncbi.nlm.nih.gov/pubmed/19091860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01690-08
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https://ncbi.nlm.nih.gov/pmc/articles/PMC2643730/
https://ncbi.nlm.nih.gov/pubmed/19091860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01690-08

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